| Title |
Comprehensive Gene Expression Analysis of Cerebral Cortices from Mature Rats After Neonatal Hypoxic–Ischemic Brain Injury
|
|---|---|
| Published in |
Journal of Molecular Neuroscience, June 2012
|
| DOI | 10.1007/s12031-012-9830-5 |
| Pubmed ID | |
| Authors |
Toshio Kojima, Yuto Ueda, Akira Sato, Hiroshi Sameshima, Tsuyomu Ikenoue |
| Abstract |
Neonatal hypoxic-ischemic (HI) encephalopathy can lead to severe brain damage and is a common cause of neurological handicaps in adulthood. To elucidate the molecular events occurring in cerebral cortices of mature rats (8 weeks old) after neonatal HI brain insult, we performed comprehensive gene expression and gene network analyses using a DNA microarray system (Agilent 4x44K). A rat model of neonatal HI encephalopathy (Rice model) was obtained by unilateral ligation of the common carotid artery of 7-day-old rats with hypoxia (exposure to 8 % oxygen). Due to the HI insult-related breakdown of the ipsilateral hemisphere in the brain, RNAs were prepared from the contralateral cerebral cortices of 8-week-old rats and analyzed by DNA microarray. Biofunctional analysis of differentially regulated genes revealed that many upregulated genes were related to cell death signaling, such as the arachidonic acid cascade. In contrast, many downregulated genes were related to gene expression, reflecting progressive damage by the HI insult, even within the contralateral cerebral hemisphere. |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 6% |
| Finland | 1 | 6% |
| Unknown | 15 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 24% |
| Student > Ph. D. Student | 2 | 12% |
| Researcher | 2 | 12% |
| Other | 1 | 6% |
| Professor | 1 | 6% |
| Other | 3 | 18% |
| Unknown | 4 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 29% |
| Neuroscience | 4 | 24% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Medicine and Dentistry | 1 | 6% |
| Engineering | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 5 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2013.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Journal of Molecular Neuroscience
#485
of 1,643 outputs
Outputs of similar age
#60,418
of 179,566 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#8
of 24 outputs
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We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.