Title |
The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination
|
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Published in |
Mammalian Genome, September 1995
|
DOI | 10.1007/bf00352371 |
Pubmed ID | |
Authors |
H. Klungland, D. I. Vage, L. Gomez-Raya, S. Adalsteinsson, S. Lien |
Abstract |
The melanocyte-stimulating hormone (MSH) receptor has a major function in the regulation of black (eumelanin) versus red (phaeomelanin) pigment synthesis within melanocytes. We report three alleles of the MSH-receptor gene found in cattle. A point mutation in the dominant allele ED gives black coat color, whereas a frameshift mutation, producing a prematurely terminated receptor, in homozygous e/e animals, produces red coat color. The wild-type allele E+ produces a variety of colors, reflecting the possibilities for regulating the normal receptor. Microsatellite analysis, RFLP studies, and coat color information were used to localize the MSH-receptor to bovine Chromosome (Chr) 18. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
Belgium | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 112 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 23 | 20% |
Student > Ph. D. Student | 17 | 15% |
Student > Master | 12 | 10% |
Student > Bachelor | 9 | 8% |
Student > Doctoral Student | 7 | 6% |
Other | 25 | 22% |
Unknown | 22 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 60 | 52% |
Biochemistry, Genetics and Molecular Biology | 12 | 10% |
Unspecified | 6 | 5% |
Veterinary Science and Veterinary Medicine | 5 | 4% |
Medicine and Dentistry | 4 | 3% |
Other | 3 | 3% |
Unknown | 25 | 22% |