| Title |
Purinergic signalling and cancer
|
|---|---|
| Published in |
Purinergic Signalling, June 2013
|
| DOI | 10.1007/s11302-013-9372-5 |
| Pubmed ID | |
| Authors |
Geoffrey Burnstock, Francesco Di Virgilio |
| Abstract |
Receptors for extracellular nucleotides are widely expressed by mammalian cells. They mediate a large array of responses ranging from growth stimulation to apoptosis, from chemotaxis to cell differentiation and from nociception to cytokine release, as well as neurotransmission. Pharma industry is involved in the development and clinical testing of drugs selectively targeting the different P1 nucleoside and P2 nucleotide receptor subtypes. As described in detail in the present review, P2 receptors are expressed by all tumours, in some cases to a very high level. Activation or inhibition of selected P2 receptor subtypes brings about cancer cell death or growth inhibition. The field has been largely neglected by current research in oncology, yet the evidence presented in this review, most of which is based on in vitro studies, although with a limited amount from in vivo experiments and human studies, warrants further efforts to explore the therapeutic potential of purinoceptor targeting in cancer. |
Mendeley readers
The data shown below were compiled from readership statistics for 287 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | <1% |
| Czechia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 282 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 52 | 18% |
| Student > Ph. D. Student | 51 | 18% |
| Student > Master | 35 | 12% |
| Student > Doctoral Student | 31 | 11% |
| Researcher | 30 | 10% |
| Other | 37 | 13% |
| Unknown | 51 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 68 | 24% |
| Agricultural and Biological Sciences | 52 | 18% |
| Medicine and Dentistry | 32 | 11% |
| Immunology and Microbiology | 18 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 6% |
| Other | 37 | 13% |
| Unknown | 63 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2021.
All research outputs
#3,272,848
of 22,790,780 outputs
Outputs from Purinergic Signalling
#22
of 376 outputs
Outputs of similar age
#29,200
of 196,465 outputs
Outputs of similar age from Purinergic Signalling
#2
of 5 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 376 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,465 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.