| Title |
Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses
|
|---|---|
| Published in |
Purinergic Signalling, February 2013
|
| DOI | 10.1007/s11302-013-9357-4 |
| Pubmed ID | |
| Authors |
Fenila Jacob, Claudina Pérez Novo, Claus Bachert, Koen Van Crombruggen |
| Abstract |
Extracellular ATP and related nucleotides promote a wide range of pathophysiological responses via activation of cell surface purinergic P2 receptors. Almost every cell type expresses P2 receptors and/or exhibit regulated release of ATP. In this review, we focus on the purinergic receptor distribution in inflammatory cells and their implication in diverse immune responses by providing an overview of the current knowledge in the literature related to purinergic signaling in neutrophils, macrophages, dendritic cells, lymphocytes, eosinophils, and mast cells. The pathophysiological role of purinergic signaling in these cells include among others calcium mobilization, actin polymerization, chemotaxis, release of mediators, cell maturation, cytotoxicity, and cell death. We finally discuss the therapeutic potential of P2 receptor subtype selective drugs in inflammatory conditions. |
Mendeley readers
The data shown below were compiled from readership statistics for 216 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 214 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 16% |
| Researcher | 34 | 16% |
| Student > Master | 29 | 13% |
| Student > Bachelor | 23 | 11% |
| Student > Doctoral Student | 20 | 9% |
| Other | 30 | 14% |
| Unknown | 45 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 41 | 19% |
| Agricultural and Biological Sciences | 36 | 17% |
| Medicine and Dentistry | 31 | 14% |
| Immunology and Microbiology | 17 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 5% |
| Other | 26 | 12% |
| Unknown | 55 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2023.
All research outputs
#4,854,681
of 23,392,375 outputs
Outputs from Purinergic Signalling
#38
of 384 outputs
Outputs of similar age
#53,824
of 291,015 outputs
Outputs of similar age from Purinergic Signalling
#1
of 2 outputs
Altmetric has tracked 23,392,375 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 384 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,015 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them