| Title |
Bone Marrow Mesenchymal Cells: How Do They Contribute to Tissue Repair and Are They Really Stem Cells?
|
|---|---|
| Published in |
Archivum Immunologiae et Therapiae Experimentalis, July 2011
|
| DOI | 10.1007/s00005-011-0139-9 |
| Pubmed ID | |
| Authors |
Yasumasa Kuroda, Masaaki Kitada, Shohei Wakao, Mari Dezawa |
| Abstract |
Adult stem cells typically generate the cell types of the tissue in which they reside, and thus the range of their differentiation is considered limited. Bone marrow mesenchymal stem cells (MSCs) are different from other somatic stem cells in that they differentiate not only into the same mesodermal-lineage such as bone, cartilage, and adipocytes but also into other lineages of ectodermal and endodermal cells. Thus, MSCs are a unique type of adult stem cells. In addition, MSCs home to damaged sites, differentiate into cells specific to the tissue and contribute to tissue repair. Therefore, application of MSCs in the treatment of various diseases, including liver dysfunction, myocardial infarction, and central nervous system repair, has been initiated. Because MSCs are generally harvested as adherent cells from bone marrow aspirates, however, they comprise heterogeneous cell populations and their wide-ranging differentiation ability and repair functions are not yet clear. Recent evidence suggests that a very small subpopulation of cells that assume a repair function with the ability to differentiate into trilineage cells resides among human MSCs and effective utilization of such cells is expected to improve the repair effect of MSCs. This review summarizes recent advances in the clarification of MSC properties and discusses future perspectives. |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 2 | 2% |
| Canada | 1 | <1% |
| China | 1 | <1% |
| Japan | 1 | <1% |
| Jordan | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 94 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 23% |
| Student > Ph. D. Student | 22 | 22% |
| Student > Master | 9 | 9% |
| Student > Bachelor | 8 | 8% |
| Professor > Associate Professor | 8 | 8% |
| Other | 13 | 13% |
| Unknown | 18 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 28% |
| Medicine and Dentistry | 22 | 22% |
| Biochemistry, Genetics and Molecular Biology | 18 | 18% |
| Engineering | 5 | 5% |
| Neuroscience | 3 | 3% |
| Other | 5 | 5% |
| Unknown | 20 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2018.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Archivum Immunologiae et Therapiae Experimentalis
#103
of 385 outputs
Outputs of similar age
#42,181
of 119,654 outputs
Outputs of similar age from Archivum Immunologiae et Therapiae Experimentalis
#2
of 3 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 385 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 119,654 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.