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Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin

Overview of attention for article published in Febs Letters, March 2003
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Title
Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin
Published in
Febs Letters, March 2003
DOI 10.1016/s0014-5793(03)00216-3
Pubmed ID
Authors

Allan M Torres, Paramjit Bansal, Paul F Alewood, Jane A Bursill, Philip W Kuchel, Jamie I Vandenberg

Abstract

The three-dimensional structure of chemically synthesized CnErg1 (Ergtoxin), which specifically blocks HERG (human ether-a-go-go-related gene) K+ channels, was determined by nuclear magnetic resonance spectroscopy. CnErg1 consists of a triple-stranded beta-sheet and an alpha-helix, as is typical of K+ channel scorpion toxins. The peptide structure differs from the canonical structures in that the first beta-strand is shorter and is nearer to the second beta-strand rather than to the third beta-strand on the C-terminus. There is also a large hydrophobic patch on the surface of the toxin, surrounding a central lysine residue, Lys13. We postulate that this hydrophobic patch is likely to form part of the binding surface of the toxin.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 6%
United States 1 3%
Unknown 33 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 28%
Other 6 17%
Student > Doctoral Student 3 8%
Student > Bachelor 3 8%
Professor 2 6%
Other 8 22%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 28%
Chemistry 6 17%
Biochemistry, Genetics and Molecular Biology 5 14%
Pharmacology, Toxicology and Pharmaceutical Science 4 11%
Computer Science 1 3%
Other 3 8%
Unknown 7 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2014.
All research outputs
#8,543,833
of 25,394,764 outputs
Outputs from Febs Letters
#4,923
of 14,379 outputs
Outputs of similar age
#21,003
of 62,198 outputs
Outputs of similar age from Febs Letters
#36
of 115 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,379 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,198 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 115 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.