| Title |
Activity-Dependent Neuroprotective Protein Modulates Its Own Gene Expression
|
|---|---|
| Published in |
Journal of Molecular Neuroscience, June 2011
|
| DOI | 10.1007/s12031-011-9562-y |
| Pubmed ID | |
| Authors |
Moutasem S. Aboonq, Sylvia A. Vasiliou, Kate Haddley, John P. Quinn, Vivien J. Bubb |
| Abstract |
We investigated whether activity-dependent neuroprotective protein (ADNP) could autoregulate its own expression. Both the endogenous ADNP gene and reporter gene constructs were analysed in response to overexpression of ADNP, supplied either as wild-type ADNP or a mutant form lacking the NAP motif, a motif which has neuroprotective properties. Overexpression of these two forms of ADNP resulted in both decreased endogenous ADNP expression and repressed ADNP promoter-directed reporter gene activity. Chromatin immunoprecipitation demonstrated the ability of ADNP to bind to its own promoter which is consistent with its action as a repressor of both promoter-supported and endogenous ADNP expression. |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 4% |
| Unknown | 26 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 26% |
| Student > Ph. D. Student | 5 | 19% |
| Student > Master | 4 | 15% |
| Researcher | 4 | 15% |
| Professor > Associate Professor | 2 | 7% |
| Other | 0 | 0% |
| Unknown | 5 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 33% |
| Agricultural and Biological Sciences | 8 | 30% |
| Neuroscience | 3 | 11% |
| Medicine and Dentistry | 1 | 4% |
| Nursing and Health Professions | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 5 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2014.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Journal of Molecular Neuroscience
#485
of 1,643 outputs
Outputs of similar age
#45,844
of 123,943 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#7
of 23 outputs
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