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Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade

Overview of attention for article published in Cell, April 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
157 X users
patent
3 patents
facebook
5 Facebook pages
googleplus
6 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
115 Dimensions

Readers on

mendeley
270 Mendeley
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Title
Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade
Published in
Cell, April 2018
DOI 10.1016/j.cell.2018.03.026
Pubmed ID
Authors

Sachet A. Shukla, Pavan Bachireddy, Bastian Schilling, Christina Galonska, Qian Zhan, Clyde Bango, Rupert Langer, Patrick C. Lee, Daniel Gusenleitner, Derin B. Keskin, Mehrtash Babadi, Arman Mohammad, Andreas Gnirke, Kendell Clement, Zachary J. Cartun, Eliezer M. Van Allen, Diana Miao, Ying Huang, Alexandra Snyder, Taha Merghoub, Jedd D. Wolchok, Levi A. Garraway, Alexander Meissner, Jeffrey S. Weber, Nir Hacohen, Donna Neuberg, Patrick R. Potts, George F. Murphy, Christine G. Lian, Dirk Schadendorf, F. Stephen Hodi, Catherine J. Wu

Abstract

CTLA-4 immune checkpoint blockade is clinically effective in a subset of patients with metastatic melanoma. We identify a subcluster of MAGE-A cancer-germline antigens, located within a narrow 75 kb region of chromosome Xq28, that predicts resistance uniquely to blockade of CTLA-4, but not PD-1. We validate this gene expression signature in an independent anti-CTLA-4-treated cohort and show its specificity to the CTLA-4 pathway with two independent anti-PD-1-treated cohorts. Autophagy, a process critical for optimal anti-cancer immunity, has previously been shown to be suppressed by the MAGE-TRIM28 ubiquitin ligase in vitro. We now show that the expression of the key autophagosome component LC3B and other activators of autophagy are negatively associated with MAGE-A protein levels in human melanomas, including samples from patients with resistance to CTLA-4 blockade. Our findings implicate autophagy suppression in resistance to CTLA-4 blockade in melanoma, suggesting exploitation of autophagy induction for potential therapeutic synergy with CTLA-4 inhibitors.

X Demographics

X Demographics

The data shown below were collected from the profiles of 157 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 270 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 270 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 70 26%
Student > Ph. D. Student 40 15%
Other 22 8%
Student > Master 16 6%
Student > Bachelor 16 6%
Other 40 15%
Unknown 66 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 57 21%
Immunology and Microbiology 43 16%
Medicine and Dentistry 42 16%
Agricultural and Biological Sciences 33 12%
Pharmacology, Toxicology and Pharmaceutical Science 6 2%
Other 12 4%
Unknown 77 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 122. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2023.
All research outputs
#346,661
of 25,563,770 outputs
Outputs from Cell
#1,874
of 17,224 outputs
Outputs of similar age
#7,880
of 343,793 outputs
Outputs of similar age from Cell
#58
of 174 outputs
Altmetric has tracked 25,563,770 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,224 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.4. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,793 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 174 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.