| Title |
Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis
|
|---|---|
| Published in |
Journal of Neural Transmission, November 2008
|
| DOI | 10.1007/s00702-008-0156-y |
| Pubmed ID | |
| Authors |
Daniel Martins-de-Souza, Wagner F. Gattaz, Andrea Schmitt, Christiane Rewerts, Sérgio Marangoni, José C. Novello, Giuseppina Maccarrone, Christoph W. Turck, Emmanuel Dias-Neto |
| Abstract |
Global proteomic analysis of post-mortem anterior temporal lobe samples from schizophrenia patients and non-schizophrenia individuals was performed using stable isotope labeling and shotgun proteomics. Our analysis resulted in the identification of 479 proteins, 37 of which showed statistically significant differential expression. Pathways affected by differential protein expression include transport, signal transduction, energy pathways, cell growth and maintenance and protein metabolism. The collection of protein alterations identified here reinforces the importance of myelin/oligodendrocyte and calcium homeostasis in schizophrenia, and reveals a number of new potential markers that may contribute to the understanding of the pathogenesis of this complex disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Hungary | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 92 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 18% |
| Researcher | 15 | 16% |
| Student > Bachelor | 12 | 13% |
| Student > Master | 10 | 11% |
| Professor | 7 | 7% |
| Other | 17 | 18% |
| Unknown | 17 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 32% |
| Neuroscience | 14 | 15% |
| Biochemistry, Genetics and Molecular Biology | 12 | 13% |
| Medicine and Dentistry | 10 | 11% |
| Psychology | 3 | 3% |
| Other | 9 | 9% |
| Unknown | 17 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Journal of Neural Transmission
#631
of 1,765 outputs
Outputs of similar age
#47,604
of 165,361 outputs
Outputs of similar age from Journal of Neural Transmission
#2
of 7 outputs
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So far Altmetric has tracked 1,765 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
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