| Title |
Peptides as drug delivery vehicles across biological barriers
|
|---|---|
| Published in |
Journal of Pharmaceutical Investigation, December 2017
|
| DOI | 10.1007/s40005-017-0374-0 |
| Pubmed ID | |
| Authors |
Debadyuti Ghosh, Xiujuan Peng, Jasmim Leal, Rashmi P. Mohanty |
| Abstract |
Peptides are small biological molecules that are attractive in drug delivery and materials engineering for applications including therapeutics, molecular building blocks and cell-targeting ligands. Peptides are small but can possess complexity and functionality as larger proteins. Due to their intrinsic properties, peptides are able to overcome the physiological and transport barriers presented by diseases. In this review, we discuss the progress of identifying and using peptides to shuttle across biological barriers and facilitate transport of drugs and drug delivery systems for improved therapy. Here, the focus of this review is on rationally designed, phage display peptides, and even endogenous peptides as carriers to penetrate biological barriers, specifically the blood-brain barrier(BBB), the gastrointestinal tract (GI), and the solid tumor microenvironment (T). We will discuss recent advances of peptides as drug carriers in these biological environments. From these findings, challenges and potential opportunities to iterate and improve peptide-based approaches will be discussed to translate their promise towards the clinic to deliver drugs for therapeutic efficacy. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 86 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 22% |
| Student > Master | 9 | 10% |
| Researcher | 7 | 8% |
| Professor | 6 | 7% |
| Student > Doctoral Student | 6 | 7% |
| Other | 9 | 10% |
| Unknown | 30 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 10% |
| Chemistry | 6 | 7% |
| Chemical Engineering | 4 | 5% |
| Agricultural and Biological Sciences | 3 | 3% |
| Other | 12 | 14% |
| Unknown | 41 | 48% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2022.
All research outputs
#5,836,113
of 23,202,641 outputs
Outputs from Journal of Pharmaceutical Investigation
#20
of 68 outputs
Outputs of similar age
#113,003
of 440,029 outputs
Outputs of similar age from Journal of Pharmaceutical Investigation
#2
of 5 outputs
Altmetric has tracked 23,202,641 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 68 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 440,029 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.