| Title |
Lack of functional relevance of isolated cell damage in transplants of Parkinson’s disease patients
|
|---|---|
| Published in |
Journal of Neurology, August 2009
|
| DOI | 10.1007/s00415-009-5242-z |
| Pubmed ID | |
| Authors |
Oliver Cooper, Arnar Astradsson, Penny Hallett, Harold Robertson, Ivar Mendez, Ole Isacson |
| Abstract |
Postmortem analyses from clinical neural transplantation trials of several subjects with Parkinson's disease revealed surviving grafted dopaminergic neurons after more than a decade. A subset of these subjects displayed isolated dopaminergic neurons within the grafts that contained Lewy body-like structures. In this review, we discuss why this isolated cell damage is unlikely to affect the overall graft function and how we can use these observations to help us to understand age-related neurodegeneration and refine our future cell replacement therapies. |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 4% |
| Unknown | 54 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 27% |
| Student > Master | 9 | 16% |
| Other | 6 | 11% |
| Student > Ph. D. Student | 4 | 7% |
| Student > Bachelor | 3 | 5% |
| Other | 10 | 18% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 13 | 23% |
| Agricultural and Biological Sciences | 12 | 21% |
| Medicine and Dentistry | 7 | 13% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Psychology | 3 | 5% |
| Other | 6 | 11% |
| Unknown | 11 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2014.
All research outputs
#4,697,128
of 22,790,780 outputs
Outputs from Journal of Neurology
#1,204
of 4,475 outputs
Outputs of similar age
#17,874
of 90,509 outputs
Outputs of similar age from Journal of Neurology
#7
of 24 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,475 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 90,509 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.