| Title |
The exocyst complex in exocytosis and cell migration
|
|---|---|
| Published in |
Protoplasma, October 2011
|
| DOI | 10.1007/s00709-011-0330-1 |
| Pubmed ID | |
| Authors |
Jianglan Liu, Wei Guo |
| Abstract |
Exocytosis is a fundamental membrane trafficking event in eukaryotic cells in which membrane proteins or lipids are incorporated into the plasma membrane and vesicle contents are secreted to the exterior of the cell. The exocyst, an evolutionarily conserved octameric protein complex, plays a crucial role in the targeting of secretory vesicles to the plasma membrane during exocytosis. The exocyst has been shown to be involved in diverse cellular processes requiring polarized exocytosis such as yeast budding, epithelial polarity establishment, and neurite outgrowth. Recently, the exocyst has also been implicated in cell migration through mechanisms independent of its role in exocytosis. In this review, we will first summarize our knowledge on the exocyst complex at a molecular and structural level. Then, we will discuss the specific functions of the exocyst in exocytosis in various cell types. Finally, we will review the emerging roles of the exocyst during cell migration and tumor cell invasion. |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Germany | 2 | 1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Canada | 1 | <1% |
| United Kingdom | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 137 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 23% |
| Researcher | 30 | 20% |
| Student > Bachelor | 23 | 16% |
| Student > Master | 14 | 9% |
| Professor > Associate Professor | 8 | 5% |
| Other | 21 | 14% |
| Unknown | 18 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 72 | 49% |
| Biochemistry, Genetics and Molecular Biology | 34 | 23% |
| Neuroscience | 10 | 7% |
| Unspecified | 3 | 2% |
| Chemistry | 3 | 2% |
| Other | 9 | 6% |
| Unknown | 17 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2012.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Protoplasma
#133
of 970 outputs
Outputs of similar age
#46,156
of 136,571 outputs
Outputs of similar age from Protoplasma
#2
of 9 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 970 research outputs from this source. They receive a mean Attention Score of 2.4. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 136,571 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.