| Title |
Solution NMR structures reveal a distinct architecture and provide first structures for protein domain family PF04536
|
|---|---|
| Published in |
Journal of Structural and Functional Genomics, December 2011
|
| DOI | 10.1007/s10969-011-9122-2 |
| Pubmed ID | |
| Authors |
Alexander Eletsky, Thomas B. Acton, Rong Xiao, John K. Everett, Gaetano T. Montelione, Thomas Szyperski |
| Abstract |
The protein family (Pfam) PF04536 is a broadly conserved domain family of unknown function (DUF477), with more than 1,350 members in prokaryotic and eukaryotic proteins. High-quality NMR structures of the N-terminal domain comprising residues 41-180 of the 684-residue protein CG2496 from Corynebacterium glutamicum and the N-terminal domain comprising residues 35-182 of the 435-residue protein PG0361 from Porphyromonas gingivalis both exhibit an α/β fold comprised of a four-stranded β-sheet, three α-helices packed against one side of the sheet, and a fourth α-helix attached to the other side. In spite of low sequence similarity (18%) assessed by structure-based sequence alignment, the two structures are globally quite similar. However, moderate structural differences are observed for the relative orientation of two of the four helices. Comparison with known protein structures reveals that the α/β architecture of CG2496(41-180) and PG0361(35-182) has previously not been characterized. Moreover, calculation of surface charge potential and identification of surface clefts indicate that the two domains very likely have different functions. |
Mendeley readers
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 7% |
| Unknown | 13 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 29% |
| Researcher | 4 | 29% |
| Student > Master | 2 | 14% |
| Student > Bachelor | 1 | 7% |
| Professor > Associate Professor | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 1 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 57% |
| Biochemistry, Genetics and Molecular Biology | 3 | 21% |
| Earth and Planetary Sciences | 1 | 7% |
| Chemistry | 1 | 7% |
| Unknown | 1 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2012.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Journal of Structural and Functional Genomics
#26
of 107 outputs
Outputs of similar age
#70,590
of 243,679 outputs
Outputs of similar age from Journal of Structural and Functional Genomics
#1
of 2 outputs
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So far Altmetric has tracked 107 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
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