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Mendeley readers
Attention Score in Context
| Title |
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1
|
|---|---|
| Published in |
Nature Genetics, August 2010
|
| DOI | 10.1038/ng.648 |
| Pubmed ID | |
| Authors |
Li-Dong Wang, Fu-You Zhou, Xue-Min Li, Liang-Dan Sun, Xin Song, Yan Jin, Jiang-Man Li, Guo-Qiang Kong, Hong Qi, Juan Cui, Lian-Qun Zhang, Jie-Zhi Yang, Ji-Lin Li, Xing-Chuan Li, Jing-Li Ren, Zhi-Cai Liu, Wen-Jun Gao, Ling Yuan, Wu Wei, Yan-Rui Zhang, Wei-Peng Wang, Ilyar Sheyhidin, Feng Li, Bao-Ping Chen, Shu-Wei Ren, Bin Liu, Dan Li, Jian-Wei Ku, Zong-Min Fan, Sheng-Li Zhou, Zhi-Gang Guo, Xue-Ke Zhao, Na Liu, Yong-Hong Ai, Fang-Fang Shen, Wen-Yan Cui, Shuang Song, Tao Guo, Jing Huang, Chao Yuan, Jia Huang, Yue Wu, Wen-Bin Yue, Chang-Wei Feng, Hong-Lei Li, Yan Wang, Jin-Ya Tian, Yue Lu, Yi Yuan, Wen-Liang Zhu, Min Liu, Wen-Jing Fu, Xia Yang, Han-Jing Wang, Suo-Li Han, Jie Chen, Min Han, Hai-Yan Wang, Peng Zhang, Xiu-Min Li, Jin-Cheng Dong, Guo-Lan Xing, Ran Wang, Ming Guo, Zhi-Wei Chang, Hai-Lin Liu, Li Guo, Zhi-Qing Yuan, Hai Liu, Qin Lu, Liu-Qin Yang, Fu-Guo Zhu, Xiu-Feng Yang, Xiao-Shan Feng, Zhou Wang, Yin Li, She-Gan Gao, Qirenwang Qige, Long-Tang Bai, Wen-Jun Yang, Guang-Yan Lei, Zhong-Ying Shen, Long-Qi Chen, En-Min Li, Li-Yan Xu, Zhi-Yong Wu, Wei-Ke Cao, Jian-Po Wang, Zhi-Qin Bao, Ji-Li Chen, Guang-Cheng Ding, Xiang Zhuang, Ying-Fa Zhou, Hou-Feng Zheng, Zheng Zhang, Xian-Bo Zuo, Zi-Ming Dong, Dong-Mei Fan, Xin He, Jin Wang, Qi Zhou, Qin-Xian Zhang, Xin-Ying Jiao, Shi-Yong Lian, Ai-Fang Ji, Xiao-Mei Lu, Jin-Sheng Wang, Fu-Bao Chang, Chang-Dong Lu, Zhi-Guo Chen, Jian-Jun Miao, Zeng-Lin Fan, Ruo-Bai Lin, Tai-Jiang Liu, Jin-Chang Wei, Qing-Peng Kong, Yu Lan, Yu-Jing Fan, Fu-Sheng Gao, Tian-Yun Wang, Dong Xie, Shu-Qing Chen, Wan-Cai Yang, Jun-Yan Hong, Liang Wang, Song-Liang Qiu, Zhi-Ming Cai, Xue-Jun Zhang |
| Abstract |
We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA. |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| South Africa | 1 | <1% |
| China | 1 | <1% |
| Belgium | 1 | <1% |
| Japan | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 136 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 21% |
| Student > Ph. D. Student | 26 | 18% |
| Student > Master | 17 | 12% |
| Professor | 10 | 7% |
| Professor > Associate Professor | 9 | 6% |
| Other | 24 | 17% |
| Unknown | 27 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 23% |
| Medicine and Dentistry | 31 | 22% |
| Biochemistry, Genetics and Molecular Biology | 23 | 16% |
| Chemistry | 5 | 3% |
| Chemical Engineering | 4 | 3% |
| Other | 19 | 13% |
| Unknown | 28 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2022.
All research outputs
#4,849,926
of 23,371,053 outputs
Outputs from Nature Genetics
#4,301
of 7,264 outputs
Outputs of similar age
#20,267
of 96,144 outputs
Outputs of similar age from Nature Genetics
#30
of 47 outputs
Altmetric has tracked 23,371,053 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,264 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.7. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,144 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.