| Title |
Exploration of geosmin synthase from Streptomyces peucetius ATCC 27952 by deletion of doxorubicin biosynthetic gene cluster
|
|---|---|
| Published in |
Journal of Industrial Microbiology & Biotechnology, June 2009
|
| DOI | 10.1007/s10295-009-0605-0 |
| Pubmed ID | |
| Authors |
Bijay Singh, Tae-Jin Oh, Jae Kyung Sohng |
| Abstract |
Thorough investigation of Streptomyces peucetius ATCC 27952 genome revealed a sesquiterpene synthase, named spterp13, which encodes a putative protein of 732 amino acids with significant similarity to S. avermitilis MA-4680 (SAV2163, GeoA) and S. coelicolor A3(2) (SCO6073). The proteins encoded by SAV2163 and SCO6073 produce geosmin in the respective strains. However, the spterp13 gene seemed to be silent in S. peucetius. Deletion of the doxorubicin gene cluster from S. peucetius resulted in increased cell growth rate along with detectable production of geosmin. When we over expressed the spterp13 gene in S. peucetius DM07 under the control of an ermE* promoter, 2.4 +/- 0.4-fold enhanced production of geosmin was observed. |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | 3% |
| Unknown | 30 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 26% |
| Student > Ph. D. Student | 6 | 19% |
| Professor | 3 | 10% |
| Professor > Associate Professor | 2 | 6% |
| Other | 2 | 6% |
| Other | 4 | 13% |
| Unknown | 6 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 35% |
| Biochemistry, Genetics and Molecular Biology | 5 | 16% |
| Environmental Science | 2 | 6% |
| Immunology and Microbiology | 2 | 6% |
| Chemistry | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 7 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2013.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Journal of Industrial Microbiology & Biotechnology
#439
of 1,301 outputs
Outputs of similar age
#37,375
of 110,687 outputs
Outputs of similar age from Journal of Industrial Microbiology & Biotechnology
#11
of 19 outputs
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