| Title |
Purinergic transmission in the central nervous system
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, May 2006
|
| DOI | 10.1007/s00424-006-0060-y |
| Pubmed ID | |
| Authors |
R. Alan North, Alexei Verkhratsky |
| Abstract |
The adenosine 5'-triphosphate (ATP), discovered in 1929 by Karl Lohman, Cyrus Hartwell Fiske, and Yellagaprada SubbaRow, acts as an important extracellular signaling molecule. In the CNS, ATP can be released from synaptic terminals, either on its own or together with other neurotransmitters. After the release from the presynaptic terminals, ATP binds to a plethora of ionotropic and metabotropic receptors, which mediate its action as an excitatory neurotransmitter. Furthermore, ATP also acts as an important mediator in neuronal-glial communications because glial cells are endowed with numerous ATP receptors, which trigger Ca(2+) signaling events and membrane currents in both macro and microglia. In addition, ATP can be released from astroglial cells, thereby acting as a mediator of glial-glial and glial-neuronal signaling. |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Canada | 1 | 1% |
| Slovenia | 1 | 1% |
| China | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 74 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 23% |
| Student > Ph. D. Student | 17 | 22% |
| Student > Master | 12 | 15% |
| Student > Bachelor | 7 | 9% |
| Student > Doctoral Student | 4 | 5% |
| Other | 12 | 15% |
| Unknown | 9 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 39% |
| Neuroscience | 14 | 18% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Medicine and Dentistry | 6 | 8% |
| Immunology and Microbiology | 2 | 3% |
| Other | 7 | 9% |
| Unknown | 12 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2023.
All research outputs
#3,925,330
of 23,815,455 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#164
of 1,973 outputs
Outputs of similar age
#10,043
of 67,334 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#1
of 15 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,973 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 67,334 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.