| Title |
Adaptive Immune Responses in CNS Autoimmune Disease: Mechanisms and Therapeutic Opportunities
|
|---|---|
| Published in |
Journal of Neuroimmune Pharmacology, April 2013
|
| DOI | 10.1007/s11481-013-9453-9 |
| Pubmed ID | |
| Authors |
Rhoanne C. McPherson, Stephen M. Anderton |
| Abstract |
The processes underlying autoimmune CNS inflammation are complex, but key roles for autoimmune lymphocytes seem inevitable, based on clinical investigations in multiple sclerosis (MS) and related diseases such as neuromyelitis optica, together with the known pathogenic activity of T cells in experimental autoimmune encephalomyelitis (EAE) models. Despite intense investigation, the details of etiopathology in these diseases have been elusive. Here we describe recent advances in the rodent models that begin to allow a map of pathogenic and protective immunity to be drawn. This map might illuminate previous successful and unsuccessful therapeutic strategies targeting particular pathways, whilst also providing better opportunities for the future, leading to tailored intervention based on understanding the quality of each individual's autoimmune response. |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 3% |
| Canada | 1 | 3% |
| Brazil | 1 | 3% |
| Unknown | 36 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 23% |
| Professor > Associate Professor | 6 | 15% |
| Student > Ph. D. Student | 5 | 13% |
| Student > Master | 5 | 13% |
| Student > Postgraduate | 3 | 8% |
| Other | 9 | 23% |
| Unknown | 2 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 31% |
| Agricultural and Biological Sciences | 6 | 15% |
| Neuroscience | 6 | 15% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Immunology and Microbiology | 3 | 8% |
| Other | 4 | 10% |
| Unknown | 5 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2023.
All research outputs
#8,064,660
of 24,217,893 outputs
Outputs from Journal of Neuroimmune Pharmacology
#241
of 583 outputs
Outputs of similar age
#68,243
of 202,674 outputs
Outputs of similar age from Journal of Neuroimmune Pharmacology
#10
of 19 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 583 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.