| Title |
Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer
|
|---|---|
| Published in |
Virchows Archiv, January 2007
|
| DOI | 10.1007/s00428-006-0360-9 |
| Pubmed ID | |
| Authors |
Guangying Qi, Ikuko Ogawa, Yasusei Kudo, Mutsumi Miyauchi, B. S. M. S. Siriwardena, Fumio Shimamoto, Masaaki Tatsuka, Takashi Takata |
| Abstract |
Aurora-B kinase is a chromosomal passenger protein and is essential for chromosome segregation and cytokinesis. Aurora-B overexpression in various cancer cells induces chromosomal number instability to produce multinuclearity and relates to metastasis. Here, we examined the expression of Aurora-B in oral squamous cell carcinoma (OSCC) to elucidate the relationship between Aurora-B expression and clinico-pathological findings by immunohistochemistry. Aurora-B expression was observed in normal oral squamous epithelia and OSCC cases, but the number of positive cells was significantly higher in OSCC than in normal squamous epithelium (p < 0.01). The labeling index of Aurora-B was significantly correlated with lymph node metastasis (p < 0.01) and histological grades of differentiation (p < 0.01). We also compared Aurora-B expression with Ki-67 expression and a positive correlation was found (p < 0.0001). Moreover, Aurora-B expression is significantly more frequent in multinuclear tumor cells than in total tumor cells. In summary, we found that Aurora-B expression was well correlated with cell proliferation, induction of multinuclear cells, histological differentiation, and metastasis in OSCC. These findings suggest that Aurora-B may be involved in tumor progression and that Aurora-B can be a new diagnostic and therapeutic target for OSCC. |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 18% |
| Student > Master | 8 | 13% |
| Student > Bachelor | 5 | 8% |
| Researcher | 5 | 8% |
| Student > Doctoral Student | 4 | 7% |
| Other | 9 | 15% |
| Unknown | 19 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 14 | 23% |
| Agricultural and Biological Sciences | 14 | 23% |
| Medicine and Dentistry | 6 | 10% |
| Chemistry | 5 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 19 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2017.
All research outputs
#3,919,343
of 26,017,215 outputs
Outputs from Virchows Archiv
#142
of 2,330 outputs
Outputs of similar age
#15,128
of 178,203 outputs
Outputs of similar age from Virchows Archiv
#1
of 8 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,330 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 93% of its peers.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them