| Title |
Exosomal miRNAs in hepatocellular carcinoma development and clinical responses
|
|---|---|
| Published in |
Journal of Hematology & Oncology, April 2018
|
| DOI | 10.1186/s13045-018-0579-3 |
| Pubmed ID | |
| Authors |
Shuangshuang Li, Jiping Yao, Mingjie Xie, Yanning Liu, Min Zheng |
| Abstract |
Hepatocellular carcinoma remains the sixth most lethal malignancy in the world. While HCC is often diagnosed via current biomarkers at a late stage, early detection of HCC has proven to be very difficult. Recent studies have focused on using exosomal miRNAs in clinical diagnostics and therapeutics, because they have improved stability in exosomes than as free miRNAs themselves. Exosomal miRNAs act through novel mechanisms for inducing cellular responses in a variety of biological circumstances. Dysregulated expression of miRNAs in exosomes can also accelerate HCC progression, including cell proliferation and metastasis, via alteration of a network of genes. Growing evidence demonstrates that exosomal miRNAs can affect many aspects of physiological and pathological conditions in HCC and indicates that miRNAs in exosomes can not only serve as sensitive biomarkers for cancer diagnostics and recurrence but can also potentially be used as therapeutics to target HCC progression. In this review, we summarize the latest findings between exosomal miRNAs and HCC, in order to better comprehend the functions and applications in HCC. Moreover, we discuss critical issues to consider when developing anti-tumor exosomal miRNAs as a novel therapeutic strategy for treating HCC in the clinic. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 13% |
| Student > Doctoral Student | 6 | 13% |
| Researcher | 5 | 11% |
| Student > Master | 4 | 9% |
| Student > Postgraduate | 3 | 7% |
| Other | 7 | 15% |
| Unknown | 15 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 24% |
| Medicine and Dentistry | 6 | 13% |
| Immunology and Microbiology | 3 | 7% |
| Engineering | 2 | 4% |
| Chemistry | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 17 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2018.
All research outputs
#15,863,447
of 23,567,572 outputs
Outputs from Journal of Hematology & Oncology
#812
of 1,223 outputs
Outputs of similar age
#211,463
of 330,267 outputs
Outputs of similar age from Journal of Hematology & Oncology
#23
of 34 outputs
Altmetric has tracked 23,567,572 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,223 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
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We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.