Title |
Diversity in the Toll-like receptor genes of the Tasmanian devil (Sarcophilus harrisii)
|
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Published in |
Immunogenetics, January 2015
|
DOI | 10.1007/s00251-014-0823-0 |
Pubmed ID | |
Authors |
Jian Cui, Yuanyuan Cheng, Katherine Belov |
Abstract |
The Tasmanian devil is an endangered marsupial species that has survived several historical bottlenecks and now has low genetic diversity. Here we characterize the Toll-like receptor (TLR) genes and their diversity in the Tasmanian devil. TLRs are a key innate immune gene family found in all animals. Ten TLR genes were identified in the Tasmanian devil genome. Unusually low levels of diversity were found in 25 devils from across Tasmania. We found two alleles at TLR2, TLR3 and TLR6. The other seven genes were monomorphic. The insurance population, which safeguards the species from extinction, has successfully managed to capture all of these TLR alleles, but concerns remain for the long-term survival of this species. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Unknown | 45 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 24% |
Student > Bachelor | 10 | 22% |
Student > Ph. D. Student | 5 | 11% |
Student > Master | 4 | 9% |
Student > Doctoral Student | 3 | 7% |
Other | 5 | 11% |
Unknown | 8 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 19 | 41% |
Biochemistry, Genetics and Molecular Biology | 8 | 17% |
Immunology and Microbiology | 5 | 11% |
Veterinary Science and Veterinary Medicine | 3 | 7% |
Environmental Science | 1 | 2% |
Other | 2 | 4% |
Unknown | 8 | 17% |