Title |
Clinicopathological Significance of microRNA-31, -143 and -145 Expression in Colorectal Cancer
|
---|---|
Published in |
Disease Markers, February 2009
|
DOI | 10.3233/dma-2009-0601 |
Pubmed ID | |
Authors |
Chao-Jie Wang, Zong-Guang Zhou, Ling Wang, Lie Yang, Bin Zhou, Jun Gu, Hong-Ying Chen, Xiao-Feng Sun |
Abstract |
We are just beginning to understand how microRNAs (miRNAs) are involved in tumor-related processes in humans. Applying real-time RT-PCR, we investigated the miR-31, miR-143 and miR-145 expression in 98 primary CRC specimens, along with the corresponding normal mucosa specimens, and analyze the relationship of their expression with clinicopathological features. Our results showed the miR-31 expression was up-regulated in CRC compared to normal mucosa (p = 0.001). Furthermore, miR-31 expression was positively related to advanced TNM stage (p = 0.026) and deeper invasion of tumors (p = 0.024). MiR-145 was down-regulated in both colon (p = 0.001) and rectal (p = 0.012) cancer. MiR-143 was only down-regulated in colon cancer (p = 0.023) but not in rectal cancer (p = 0.351). There was no relationship of miR-143 and miR-145 expression with other clinicopathological features (p > 0.05), except that the miR-145 expression was related to cancer site (p = 0.03). In conclusion, the miR-31 overexpression may be involved in the development and progression of CRC. The miR-143 and miR-145 may play a certain role in the development of colon and/or rectal cancers but not in progression of the disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
China | 1 | 2% |
Norway | 1 | 2% |
Unknown | 62 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 23% |
Student > Ph. D. Student | 14 | 22% |
Student > Bachelor | 8 | 13% |
Student > Master | 8 | 13% |
Student > Doctoral Student | 3 | 5% |
Other | 9 | 14% |
Unknown | 7 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 27% |
Medicine and Dentistry | 15 | 23% |
Biochemistry, Genetics and Molecular Biology | 13 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Computer Science | 2 | 3% |
Other | 4 | 6% |
Unknown | 11 | 17% |