| Title |
Pharmacology of proton pump inhibitors
|
|---|---|
| Published in |
Current Gastroenterology Reports, November 2008
|
| DOI | 10.1007/s11894-008-0098-4 |
| Pubmed ID | |
| Authors |
Jai Moo Shin, George Sachs |
| Abstract |
The gastric H,K-ATPase is the primary target for the treatment of acid-related diseases. Proton pump inhibitors (PPIs) are weak bases composed of two moieties, a substituted pyridine with a primary pK(a) of about 4.0, which allows selective accumulation in the secretory canaliculus of the parietal cell, and a benzimidazole with a second pK(a) of about 1.0. PPIs are acid-activated prodrugs that convert to sulfenic acids or sulfenamides that react covalently with one or more cysteines accessible from the luminal surface of the ATPase. Because of covalent binding, their inhibitory effects last much longer than their plasma half-life. However, the short half-life of the drug in the blood and the requirement for acid activation impair their efficacy in acid suppression, particularly at night. PPIs with longer half-life promise to improve acid suppression. All PPIs give excellent healing of peptic ulcers and produce good results in reflux esophagitis. PPIs combined with antibiotics eradicate Helicobacter pylori. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 591 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Israel | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 589 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 143 | 24% |
| Student > Master | 88 | 15% |
| Student > Ph. D. Student | 38 | 6% |
| Researcher | 36 | 6% |
| Student > Postgraduate | 30 | 5% |
| Other | 67 | 11% |
| Unknown | 189 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 143 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 89 | 15% |
| Biochemistry, Genetics and Molecular Biology | 39 | 7% |
| Agricultural and Biological Sciences | 35 | 6% |
| Nursing and Health Professions | 27 | 5% |
| Other | 57 | 10% |
| Unknown | 201 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 72. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2023.
All research outputs
#604,475
of 26,017,215 outputs
Outputs from Current Gastroenterology Reports
#12
of 611 outputs
Outputs of similar age
#1,784
of 184,835 outputs
Outputs of similar age from Current Gastroenterology Reports
#1
of 18 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 611 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,835 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.