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Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia

Overview of attention for article published in Nature, June 1993
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

news
1 news outlet
wikipedia
1 Wikipedia page

Citations

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664 Dimensions

Readers on

mendeley
146 Mendeley
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Title
Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia
Published in
Nature, June 1993
DOI 10.1038/363543a0
Pubmed ID
Authors

Elspeth M. McLachlan, Wilfrid Jänig, Marshall Devor, Martin Michaelis

Abstract

In humans, trauma to a peripheral nerve may be followed by chronic pain syndromes which are only relieved by blockade of the effects of sympathetic impulse traffic. It is presumed that, after the lesion, noradrenaline released by activity of sympathetic postganglionic axons excites primary afferent neurons by activating alpha-adrenoceptors, generating signals that enter the 'pain pathways' of the central nervous system. The site of coupling is unclear. In some patients local anaesthesia of the relevant peripheral nerve does not alleviate pain, implying that ectopic impulses arise either within the central nervous system, or in proximal parts of the primary afferent neurons. In experimentally lesioned rats, activity can originate within the dorsal root ganglia. Here we report that, after sciatic nerve ligation, noradrenergic perivascular axons in rats sprout into dorsal root ganglia and form basket-like structures around large-diameter axotomized sensory neurons; sympathetic stimulation can activate such neurons repetitively. These unusual connections provide a possible origin for abnormal discharge following peripheral nerve damage. Further, in contrast to the sprouting of intact nerve terminals into nearby denervated effector tissues in skin, muscle, sympathetic ganglia and sweat glands, the axons sprout into a target which has not been partially denervated.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Colombia 1 <1%
France 1 <1%
Germany 1 <1%
Japan 1 <1%
United Kingdom 1 <1%
Unknown 139 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 15%
Researcher 19 13%
Student > Master 18 12%
Student > Doctoral Student 10 7%
Professor > Associate Professor 10 7%
Other 35 24%
Unknown 32 22%
Readers by discipline Count As %
Medicine and Dentistry 30 21%
Agricultural and Biological Sciences 27 18%
Neuroscience 26 18%
Engineering 8 5%
Biochemistry, Genetics and Molecular Biology 5 3%
Other 16 11%
Unknown 34 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2021.
All research outputs
#2,937,708
of 22,792,160 outputs
Outputs from Nature
#47,271
of 90,838 outputs
Outputs of similar age
#1,034
of 20,662 outputs
Outputs of similar age from Nature
#33
of 171 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 90,838 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 99.3. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 20,662 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 171 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.