| Title |
MicroRNAs in Cardiometabolic Disease
|
|---|---|
| Published in |
Current Atherosclerosis Reports, April 2011
|
| DOI | 10.1007/s11883-011-0179-y |
| Pubmed ID | |
| Authors |
S. Hani Najafi-Shoushtari |
| Abstract |
Defects in homeostatic regulation of cholesterol and fatty acids are associated with major cardiometabolic risk factors that are prevalent in type 2 diabetes and atherosclerotic cardiovascular disease. Regulatory input is found at many levels; however, recent findings have revealed pivotal roles for small non-coding RNAs (microRNAs) of the endogenous RNA interference pathway in post-transcriptional control of major regulatory mechanisms underpinning cholesterol and energy homeostasis. In addition, aberrant expression of microRNAs has been implicated in marked pathophysiologic events contributing to the progression and development of atherosclerosis, including loss of endothelial integrity, vascular smooth muscle cell proliferation, neointimal hyperplasia, and foam cell formation. This review surveys the impact of microRNA-mediated regulation in biological processes governing the cholesterol/lipoprotein metabolism, fatty acid β-oxidation (eg by miR-122 and miR-33), and endothelial dysfunction related to atherosclerosis. Given the current advances in microRNA-based technologies, the clinical potential of microRNAs as novel therapeutic targets is highlighted as new alternative strategies to ameliorate cardiometabolic diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 56 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 24% |
| Researcher | 11 | 19% |
| Student > Master | 7 | 12% |
| Student > Bachelor | 5 | 9% |
| Professor > Associate Professor | 4 | 7% |
| Other | 9 | 16% |
| Unknown | 8 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 40% |
| Biochemistry, Genetics and Molecular Biology | 10 | 17% |
| Medicine and Dentistry | 10 | 17% |
| Immunology and Microbiology | 3 | 5% |
| Nursing and Health Professions | 2 | 3% |
| Other | 2 | 3% |
| Unknown | 8 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2011.
All research outputs
#7,455,523
of 22,792,160 outputs
Outputs from Current Atherosclerosis Reports
#347
of 764 outputs
Outputs of similar age
#39,833
of 108,886 outputs
Outputs of similar age from Current Atherosclerosis Reports
#3
of 9 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 764 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,886 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.