| Title |
Physiologic Characterization of Type 2 Diabetes–Related Loci
|
|---|---|
| Published in |
Current Diabetes Reports, October 2010
|
| DOI | 10.1007/s11892-010-0154-y |
| Pubmed ID | |
| Authors |
Niels Grarup, Thomas Sparsø, Torben Hansen |
| Abstract |
For the past two decades, genetics has been widely explored as a tool for unraveling the pathogenesis of diabetes. Many risk alleles for type 2 diabetes and hyperglycemia have been detected in recent years through massive genome-wide association studies and evidence exists that most of these variants influence pancreatic β-cell function. However, risk alleles in five loci seem to have a primary impact on insulin sensitivity. Investigations of more detailed physiologic phenotypes, such as the insulin response to intravenous glucose or the incretion hormones, are now emerging and give indications of more specific pathologic mechanisms for diabetes-related risk variants. Such studies have shed light on the function of some loci but also underlined the complex nature of disease mechanism. In the future, sequencing-based discovery of low-frequency variants with higher impact on intermediate diabetes-related traits is a likely scenario and identification of new pathways involved in type 2 diabetes predisposition will offer opportunities for the development of novel therapeutic and preventative approaches. |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 2 | 3% |
| United States | 1 | 1% |
| Unknown | 77 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 18% |
| Researcher | 13 | 16% |
| Student > Bachelor | 13 | 16% |
| Student > Master | 9 | 11% |
| Student > Postgraduate | 7 | 9% |
| Other | 16 | 20% |
| Unknown | 8 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 30% |
| Agricultural and Biological Sciences | 23 | 29% |
| Biochemistry, Genetics and Molecular Biology | 14 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Chemistry | 3 | 4% |
| Other | 6 | 8% |
| Unknown | 7 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2011.
All research outputs
#7,455,523
of 22,792,160 outputs
Outputs from Current Diabetes Reports
#389
of 1,006 outputs
Outputs of similar age
#35,279
of 99,148 outputs
Outputs of similar age from Current Diabetes Reports
#5
of 9 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,006 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 50% of its peers.
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We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.