| Title |
Elevated Serum Homocysteine (Hcy) Levels May Contribute to the Pathogenesis of Cerebral Infarction
|
|---|---|
| Published in |
Journal of Molecular Neuroscience, February 2015
|
| DOI | 10.1007/s12031-015-0497-6 |
| Pubmed ID | |
| Authors |
Hong-Juan Fu, Li-Bo Zhao, Ju-Jun Xue, Zhi-Xuan Wu, Yue-Ping Huang, Wei Liu, Zhan Gao |
| Abstract |
The purpose of this meta-analysis was to investigate the correlation between serum homocysteine (Hcy) levels and the pathogenesis of cerebral infarction (CI). Relevant studies involving serum Hcy levels and the pathogenesis of CI were identified using electronic database search supplemented with manual search. The search result studies were screened in accordance with our strict inclusion and exclusion criteria. Statistical analyses were conducted with Comprehensive Meta Analysis 2.0 (CMA 2.0) software. A total of 13 studies were eligible for our meta-analysis and included 1206 patients with CI and 1202 healthy controls. Our meta-analysis revealed that the serum Hcy levels in CI patients were significantly higher than those in healthy controls. Subgroup analysis based on ethnicity showed that Caucasians and Asians had significantly higher serum Hcy levels in CI patients compared to healthy controls and Africans showed no significant differences in serum Hcy levels between CI patients and controls. In conclusion, our meta-analysis reveals a strong correlation between elevated serum Hcy levels and the pathogenesis of CI, suggesting that serum Hcy levels may be an important biomarker for the early diagnosis and treatment assessment of CI. |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 8% |
| Unknown | 11 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 2 | 17% |
| Student > Bachelor | 2 | 17% |
| Student > Master | 2 | 17% |
| Professor | 1 | 8% |
| Librarian | 1 | 8% |
| Other | 2 | 17% |
| Unknown | 2 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 17% |
| Medicine and Dentistry | 2 | 17% |
| Environmental Science | 1 | 8% |
| Agricultural and Biological Sciences | 1 | 8% |
| Physics and Astronomy | 1 | 8% |
| Other | 3 | 25% |
| Unknown | 2 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2015.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Journal of Molecular Neuroscience
#1,330
of 1,643 outputs
Outputs of similar age
#330,536
of 385,282 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#23
of 32 outputs
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