| Title |
Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9)
|
|---|---|
| Published in |
Basic Research in Cardiology, January 2015
|
| DOI | 10.1007/s00395-015-0463-z |
| Pubmed ID | |
| Authors |
Rainer Schulz, Klaus-Dieter Schlüter, Ulrich Laufs |
| Abstract |
The proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising treatment target to lower serum cholesterol, a major risk factor of cardiovascular diseases. Gain-of-function mutations of PCSK9 are associated with hypercholesterolemia and increased risk of cardiovascular events. Conversely, loss-of-function mutations cause low-plasma LDL-C levels and a reduction of cardiovascular risk without known unwanted effects on individual health. Experimental studies have revealed that PCSK9 reduces the hepatic uptake of LDL-C by increasing the endosomal and lysosomal degradation of LDL receptors (LDLR). A number of clinical studies have demonstrated that inhibition of PCSK9 alone and in addition to statins potently reduces serum LDL-C concentrations. This review summarizes the current data on the regulation of PCSK9, its molecular function in lipid homeostasis and the emerging evidence on the extra-hepatic effects of PCSK9. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 1% |
| Russia | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 180 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 32 | 17% |
| Student > Ph. D. Student | 28 | 15% |
| Student > Master | 23 | 13% |
| Student > Bachelor | 23 | 13% |
| Student > Postgraduate | 8 | 4% |
| Other | 30 | 16% |
| Unknown | 40 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 24% |
| Biochemistry, Genetics and Molecular Biology | 32 | 17% |
| Agricultural and Biological Sciences | 21 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 7% |
| Chemistry | 5 | 3% |
| Other | 14 | 8% |
| Unknown | 55 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2016.
All research outputs
#6,143,584
of 22,792,160 outputs
Outputs from Basic Research in Cardiology
#144
of 644 outputs
Outputs of similar age
#83,885
of 352,088 outputs
Outputs of similar age from Basic Research in Cardiology
#5
of 10 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 644 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,088 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.