Title |
A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair
|
---|---|
Published in |
Journal of Medical Systems, February 2015
|
DOI | 10.1007/s10916-015-0208-4 |
Pubmed ID | |
Authors |
M. Fok, M. Bashir, H. Fraser, N. Strouther, A. Mason |
Abstract |
Thoraco-abdominal aneurysms (TAAA) represents a particularly lethal vascular disease that without surgical repair carries a dismal prognosis. However, there is an inherent risk from surgical repair of spinal cord ischaemia that can result in paraplegia. One method of reducing this risk is cerebrospinal fluid (CSF) drainage. We believe that the CSF contains clinically significant biomarkers that can indicate impending spinal cord ischaemia. This work therefore presents a novel measurement method for proteins, namely albumin, as a precursor to further work in this area. The work uses an interdigitated electrode (IDE) sensor and shows that it is capable of detecting various concentrations of albumin (from 0 to 100 g/L) with a high degree of repeatability at 200 MHz (R(2) = 0.991) and 4 GHz (R(2) = 0.975). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 19% |
Researcher | 5 | 19% |
Student > Bachelor | 4 | 15% |
Lecturer > Senior Lecturer | 2 | 7% |
Student > Master | 2 | 7% |
Other | 3 | 11% |
Unknown | 6 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 9 | 33% |
Medicine and Dentistry | 9 | 33% |
Business, Management and Accounting | 1 | 4% |
Unknown | 8 | 30% |