| Title |
EU-AIMS Longitudinal European Autism Project (LEAP): the autism twin cohort
|
|---|---|
| Published in |
Molecular Autism, April 2018
|
| DOI | 10.1186/s13229-018-0212-x |
| Pubmed ID | |
| Authors |
Johan Isaksson, Kristiina Tammimies, Janina Neufeld, Élodie Cauvet, Karl Lundin, Jan K. Buitelaar, Eva Loth, Declan G. M. Murphy, Will Spooren, Sven Bölte, the EU-AIMS LEAP group |
| Abstract |
EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some 'lessons learnt.' Among the twins, a diagnosis of ASD is associated with increased symptom levels of ADHD, higher rates of intellectual disability, and lower family income. For the future, we conclude that the LEAP twin cohort offers multiple options for analyses of genetic and shared and non-shared environmental factors to generate new hypotheses for the larger cohort of LEAP singletons, but particularly cross-validate and refine evidence from it. |
X Demographics
The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 4 | 15% |
| United States | 3 | 11% |
| Mexico | 3 | 11% |
| United Kingdom | 2 | 7% |
| Sweden | 2 | 7% |
| Venezuela, Bolivarian Republic of | 2 | 7% |
| Argentina | 1 | 4% |
| Canada | 1 | 4% |
| France | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 8 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 81% |
| Scientists | 3 | 11% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 130 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 12% |
| Researcher | 14 | 11% |
| Student > Bachelor | 13 | 10% |
| Student > Ph. D. Student | 12 | 9% |
| Student > Doctoral Student | 7 | 5% |
| Other | 28 | 22% |
| Unknown | 40 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 27 | 21% |
| Neuroscience | 14 | 11% |
| Medicine and Dentistry | 9 | 7% |
| Social Sciences | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Other | 24 | 18% |
| Unknown | 44 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2020.
All research outputs
#2,074,734
of 25,753,031 outputs
Outputs from Molecular Autism
#191
of 719 outputs
Outputs of similar age
#42,827
of 343,122 outputs
Outputs of similar age from Molecular Autism
#10
of 21 outputs
Altmetric has tracked 25,753,031 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 719 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.3. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,122 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.