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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Combined xanthorrhizol-curcumin exhibits synergistic growth inhibitory activity via apoptosis induction in human breast cancer cells MDA-MB-231
|
|---|---|
| Published in |
Cancer Cell International, January 2009
|
| DOI | 10.1186/1475-2867-9-1 |
| Pubmed ID | |
| Authors |
Yew Hoong Cheah, Fariza Juliana Nordin, Rozie Sarip, Thiam Tsui Tee, Hawariah Lope Pihie Azimahtol, Hasnah M Sirat, Badrul Amini Abd Rashid, Noor Rain Abdullah, Zakiah Ismail |
| Abstract |
It has been suggested that combined effect of natural products may improve the treatment effectiveness in combating proliferation of cancer cells. The present study was undertaken to evaluate the possibility that the combination of xanthorrhizol and curcumin might show synergistic growth inhibitory effect towards MDA-MB-231 human breast cancer cells via apoptosis induction. The effective dose that produced 50% growth inhibition (GI50) was calculated from the log dose-response curve of fixed-combinations of xanthorrhizol and curcumin generated from the sulforhodamine B (SRB) assay. The experimental GI50 value was used to determine the synergistic activity of the combination treatment by isobolographic analysis and combination-index method. Further investigation of mode of cell death induced by the combination treatment was conducted in the present study. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | <1% |
| Malaysia | 1 | <1% |
| India | 1 | <1% |
| Unknown | 109 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 21% |
| Student > Bachelor | 17 | 15% |
| Researcher | 13 | 12% |
| Student > Postgraduate | 8 | 7% |
| Lecturer | 7 | 6% |
| Other | 18 | 16% |
| Unknown | 26 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 16% |
| Biochemistry, Genetics and Molecular Biology | 15 | 13% |
| Chemistry | 13 | 12% |
| Medicine and Dentistry | 13 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 7% |
| Other | 12 | 11% |
| Unknown | 33 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2015.
All research outputs
#7,355,930
of 25,373,627 outputs
Outputs from Cancer Cell International
#951
of 2,231 outputs
Outputs of similar age
#44,919
of 183,450 outputs
Outputs of similar age from Cancer Cell International
#2
of 3 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 2,231 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,450 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.