| Title |
Prospective study of the association between grapefruit intake and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
|
|---|---|
| Published in |
Cancer Causes & Control, February 2009
|
| DOI | 10.1007/s10552-009-9310-6 |
| Pubmed ID | |
| Authors |
Elizabeth A. Spencer, Timothy J. Key, Paul N. Appleby, Carla H. van Gils, Anja Olsen, Anne Tjønneland, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Marina Touillaud, Maria-José Sánchez, Sheila Bingham, Kay Tee Khaw, Nadia Slimani, Rudolf Kaaks, Elio Riboli |
| Abstract |
Grapefruit inhibits cytochrome P450 3A4 and may affect estrogen metabolism. In the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined the relationships of grapefruit intake with risk of breast cancer and with serum sex hormone levels. 114,504 women with information on dietary intake of grapefruit and on reproductive and lifestyle risk factors were followed for a median 9.5 years and 3,747 incident breast cancers were identified. Fifty-nine percent of women reported eating grapefruit, 4% ate > or = 60 g/day. Cox proportional hazard models were used to estimate the hazard ratio (HR) for breast cancer according to grapefruit intake, adjusting for study centre, reproductive factors, body mass index, energy intake, and alcohol intake. Grapefruit intake was not related to the risk of breast cancer: compared with women who ate no grapefruit, women with the highest intake of > or =60 g/day had a HR of 0.93 (95% CI 0.77-1.13), p for linear trend = 0.5. There was no relationship between grapefruit intake and breast cancer risk among premenopausal women, all postmenopausal women, or postmenopausal women categorized by hormone replacement therapy use (all p>0.05). There was no association between grapefruit intake and estradiol or estrone among postmenopausal women. In this study, we found no evidence of an association between grapefruit intake and risk of breast cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 2% |
| Unknown | 57 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 21% |
| Student > Master | 9 | 16% |
| Student > Bachelor | 8 | 14% |
| Student > Ph. D. Student | 4 | 7% |
| Other | 3 | 5% |
| Other | 7 | 12% |
| Unknown | 15 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 22% |
| Medicine and Dentistry | 10 | 17% |
| Nursing and Health Professions | 5 | 9% |
| Business, Management and Accounting | 2 | 3% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 8 | 14% |
| Unknown | 18 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2015.
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#19,382,126
of 23,854,458 outputs
Outputs from Cancer Causes & Control
#1,816
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Outputs of similar age
#89,039
of 96,669 outputs
Outputs of similar age from Cancer Causes & Control
#26
of 27 outputs
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