Title |
Molecular Characteristics of Basaloid Squamous Cell Carcinoma of the Esophagus: Analysis of KRAS, BRAF, and PIK3CA Mutations and LINE-1 Methylation
|
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Published in |
Annals of Surgical Oncology, February 2015
|
DOI | 10.1245/s10434-015-4445-z |
Pubmed ID | |
Authors |
Yoshifumi Baba, Takatsugu Ishimoto, Kazuto Harada, Keisuke Kosumi, Asuka Murata, Keisuke Miyake, Yukiharu Hiyoshi, Junji Kurashige, Masaaki Iwatsuki, Shiro Iwagami, Yuji Miyamoto, Yasuo Sakamoto, Naoya Yoshida, Eiji Oki, Ken-ichi Iyama, Masayuki Watanabe, Hideo Baba |
Abstract |
Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare carcinoma with distinct characteristics, and was recently recognized as a variant of squamous cell carcinoma (SCC). We previously revealed genetic and epigenetic alterations associated with esophageal SCCs in relation to clinical outcome, including mutations in KRAS, BRAF, and PIK3CA, p53 expression, and long interspersed nucleotide element-1 (LINE-1) methylation, a surrogate marker for global DNA methylation level. In this study, we explored these features in BSCC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 2 | 14% |
Researcher | 2 | 14% |
Student > Ph. D. Student | 1 | 7% |
Professor > Associate Professor | 1 | 7% |
Student > Postgraduate | 1 | 7% |
Other | 0 | 0% |
Unknown | 7 | 50% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 29% |
Unknown | 10 | 71% |