| Title |
Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRβ/IRS-1 and Akt
|
|---|---|
| Published in |
Diabetologia, September 2009
|
| DOI | 10.1007/s00125-009-1498-1 |
| Pubmed ID | |
| Authors |
M. A. Carvalho-Filho, E. R. Ropelle, R. J. Pauli, D. E. Cintra, D. M. L. Tsukumo, L. R. Silveira, R. Curi, J. B. C. Carvalheira, L. A. Velloso, M. J. A. Saad |
| Abstract |
High-dose aspirin treatment improves fasting and postprandial hyperglycaemia in patients with type 2 diabetes, as well as in animal models of insulin resistance associated with obesity and sepsis. In this study, we investigated the effects of aspirin treatment on inducible nitric oxide synthase (iNOS)-mediated insulin resistance and on S-nitrosylation of insulin receptor (IR)-beta, IRS-1 and protein kinase B (Akt) in the muscle of diet-induced obese rats and also in iNos (also known as Nos2)-/- mice on high fat diet. |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Zealand | 1 | 2% |
| Sweden | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 41 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 8 | 18% |
| Researcher | 7 | 16% |
| Student > Ph. D. Student | 6 | 14% |
| Student > Master | 5 | 11% |
| Professor | 3 | 7% |
| Other | 8 | 18% |
| Unknown | 7 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 30% |
| Medicine and Dentistry | 8 | 18% |
| Biochemistry, Genetics and Molecular Biology | 7 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Arts and Humanities | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 11 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2017.
All research outputs
#3,029,669
of 22,792,160 outputs
Outputs from Diabetologia
#1,428
of 5,035 outputs
Outputs of similar age
#10,171
of 91,516 outputs
Outputs of similar age from Diabetologia
#7
of 37 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,035 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 91,516 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.