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Projections from the substantia nigra pars reticulata to the motor thalamus of the rat: Single axon reconstructions and immunohistochemical study

Overview of attention for article published in The Journal of Comparative Neurology, October 2001
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Title
Projections from the substantia nigra pars reticulata to the motor thalamus of the rat: Single axon reconstructions and immunohistochemical study
Published in
The Journal of Comparative Neurology, October 2001
DOI 10.1002/cne.1367
Pubmed ID
Authors

Hoa Ton Kha, David Isaac Finkelstein, Doris Tomas, John Drago, David Vaughan Pow, Malcolm Kenneth Horne

Abstract

This is a study in the rat of the distribution of specific neurotransmitters in neurones projecting from the substantia nigra reticulata (SNR) to the ventrolateral (VL) and ventromedial (VM) thalamic nuclei. Individual axons projecting from the SNR to these thalamic nuclei have also been reconstructed following small injection of the anterograde tracer dextran biotin into the the SNR. Analysis of reconstructions revealed two populations of SNR neurones projecting onto the VL and VM thalamic nuclei. One group projects directly onto the VM and VL, and the other projects to the VM/VL and to the parafascicular nucleus. In another set of experiments Fluoro-Gold was injected into the VL/VM to label SNR projection neurones retrogradely, and immunohistochemistry was performed to determine the distribution of choline acetyltransferase (ChAT), vesicular acetylcholine transporter (VAChT), gamma-aminobutyric acid (GABA), and glutamate in Fluoro-Gold-labelled SNR projection neurones. Most SNR-VL/VM thalamic projection neurones were immunoreactive to acetylcholine or glutamate, whereas only 25% of the projection neurones were found to be immunoreactive to GABA.

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The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Chile 1 2%
Hungary 1 2%
Korea, Republic of 1 2%
United Kingdom 1 2%
Unknown 56 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 19%
Student > Master 11 18%
Researcher 10 16%
Professor > Associate Professor 8 13%
Professor 5 8%
Other 9 15%
Unknown 7 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 40%
Neuroscience 16 26%
Biochemistry, Genetics and Molecular Biology 4 6%
Medicine and Dentistry 3 5%
Psychology 2 3%
Other 3 5%
Unknown 9 15%