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Facial asymmetry and genetic ancestry in Latin American admixed populations

Overview of attention for article published in American Journal of Physical Anthropology, January 2015
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Title
Facial asymmetry and genetic ancestry in Latin American admixed populations
Published in
American Journal of Physical Anthropology, January 2015
DOI 10.1002/ajpa.22688
Pubmed ID
Authors

Mirsha Quinto‐Sánchez, Kaustubh Adhikari, Victor Acuña‐Alonzo, Celia Cintas, Caio Cesar Silva de Cerqueira, Virginia Ramallo, Lucia Castillo, Arodi Farrera, Claudia Jaramillo, Williams Arias, Macarena Fuentes, Paola Everardo, Francisco de Avila, Jorge Gomez‐Valdés, Tábita Hünemeier, Shara Gibbon, Carla Gallo, Giovanni Poletti, Javier Rosique, Maria Cátira Bortolini, Samuel Canizales‐Quinteros, Francisco Rothhammer, Gabriel Bedoya, Andres Ruiz‐Linares, Rolando González‐José

Abstract

Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin-American admixed populations. To do so, three-dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome-wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and fluctuating asymmetry (FA), as well as correlations and multiple regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Results indicate that directional and FA are both significant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuals exhibit lower levels of asymmetry. Our results highlight the importance of including ancestry-admixture estimators, especially when the analyses are aimed to compare levels of asymmetries on groups differing on socioeconomic levels, as a proxy to estimate developmental noise. Am J Phys Anthropol, 2015. © 2014 Wiley Periodicals, Inc.

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Geographical breakdown

Country Count As %
United States 3 3%
Argentina 1 1%
Brazil 1 1%
Unknown 94 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 19%
Student > Bachelor 13 13%
Researcher 11 11%
Professor 10 10%
Student > Postgraduate 9 9%
Other 23 23%
Unknown 14 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 31%
Medicine and Dentistry 13 13%
Biochemistry, Genetics and Molecular Biology 11 11%
Social Sciences 8 8%
Arts and Humanities 5 5%
Other 14 14%
Unknown 17 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2015.
All research outputs
#20,739,552
of 25,477,125 outputs
Outputs from American Journal of Physical Anthropology
#3,438
of 3,879 outputs
Outputs of similar age
#267,809
of 360,244 outputs
Outputs of similar age from American Journal of Physical Anthropology
#35
of 44 outputs
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