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Transcriptional switching in macrophages associated with the peritoneal foreign body response

Overview of attention for article published in Immunology & Cell Biology, March 2014
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Title
Transcriptional switching in macrophages associated with the peritoneal foreign body response
Published in
Immunology & Cell Biology, March 2014
DOI 10.1038/icb.2014.19
Pubmed ID
Authors

Jane E Mooney, Kim M Summers, Milena Gongora, Sean M Grimmond, Julie H Campbell, David A Hume, Barbara E Rolfe

Abstract

We previously demonstrated that myeloid cells are the source of fibrotic tissue induced by foreign material implanted in the peritoneal cavity. This study utilised the MacGreen mouse, in which the Csf1r promoter directs myeloid-specific enhanced green fluorescent protein (EGFP) expression, to determine the temporal gene expression profile of myeloid subpopulations recruited to the peritoneal cavity to encapsulate implanted foreign material (cubes of boiled egg white). Cells with high EGFP expression (EGFP(hi)) were purified from exudate and encapsulating tissue at different times during the foreign body response, gene expression profiles determined using cDNA microarrays, and data clustered using the network analysis tool, Biolayout Express(3D). EGFP(hi) cells from all time points expressed high levels of Csf1r, Emr1 (encoding F4/80), Cd14 and Itgam (encoding Mac-1) providing internal validation of their myeloid nature. Exudate macrophages (days 4-7) expressed a large cluster of cell cycle genes; these were switched off in capsule cells. Early in capsule formation, Csf1r-EGFP(hi) cells expressed genes associated with tissue turnover, but later expressed both pro- and anti-inflammatory genes alongside a subset of mesenchyme-associated genes, a pattern of gene expression that adds weight to the concept of a continuum of macrophage phenotypes rather than distinct M1/M2 subsets. Moreover, rather than transdifferentiating to myofibroblasts, macrophages contributing to later stages of the peritoneal foreign body response warrant their own classification as 'fibroblastoid' macrophages.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 33%
Researcher 7 17%
Student > Bachelor 4 10%
Professor > Associate Professor 4 10%
Professor 3 7%
Other 6 14%
Unknown 4 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 36%
Biochemistry, Genetics and Molecular Biology 7 17%
Medicine and Dentistry 5 12%
Engineering 4 10%
Immunology and Microbiology 2 5%
Other 2 5%
Unknown 7 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2015.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Immunology & Cell Biology
#1,722
of 1,848 outputs
Outputs of similar age
#183,937
of 249,084 outputs
Outputs of similar age from Immunology & Cell Biology
#18
of 22 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.