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Definition of a consensus binding site for p53

Overview of attention for article published in Nature Genetics, April 1992
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

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1 news outlet
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5 X users
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31 patents
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3 Wikipedia pages

Citations

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1706 Dimensions

Readers on

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447 Mendeley
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3 CiteULike
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1 Connotea
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Title
Definition of a consensus binding site for p53
Published in
Nature Genetics, April 1992
DOI 10.1038/ng0492-45
Pubmed ID
Authors

Wafik S. El-Deiry, Scott E. Kern, Jennifer A. Pietenpol, Kenneth W. Kinzler, Bert Vogelstein

Abstract

Recent experiments have suggested that p53 action may be mediated through its interaction with DNA. We have now identified 18 human genomic clones that bind to p53 in vitro. Precise mapping of the binding sequences within these clones revealed a consensus binding site with a striking internal symmetry, consisting of two copies of the 10 base pair motif 5'-PuPuPuC(A/T)(T/A)GPyPyPy-3' separated by 0-13 base pairs. One copy of the motif was insufficient for binding, and subtle alterations of the motif, even when present in multiple copies, resulted in loss of affinity for p53. Mutants of p53, representing each of the four "hot spots" frequently altered in human cancers, failed to bind to the consensus dimer. These results define the DNA sequence elements with which p53 interacts in vitro and which may be important for p53 action in vivo.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 447 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 <1%
Germany 2 <1%
Japan 2 <1%
United Kingdom 1 <1%
Canada 1 <1%
Italy 1 <1%
Denmark 1 <1%
Switzerland 1 <1%
Singapore 1 <1%
Other 1 <1%
Unknown 432 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 113 25%
Student > Master 71 16%
Researcher 54 12%
Student > Bachelor 52 12%
Student > Doctoral Student 25 6%
Other 60 13%
Unknown 72 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 159 36%
Agricultural and Biological Sciences 119 27%
Medicine and Dentistry 37 8%
Chemistry 19 4%
Immunology and Microbiology 5 1%
Other 32 7%
Unknown 76 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2023.
All research outputs
#1,398,897
of 23,243,271 outputs
Outputs from Nature Genetics
#2,087
of 7,246 outputs
Outputs of similar age
#232
of 19,461 outputs
Outputs of similar age from Nature Genetics
#1
of 25 outputs
Altmetric has tracked 23,243,271 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,246 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 19,461 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.