Title |
Serotonin–Norepinephrine Reuptake Inhibitor and Selective Serotonin Reuptake Inhibitor Use and Risk of Fractures: A New-User Cohort Study Among US Adults Aged 50 Years and Older
|
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Published in |
CNS Drugs, February 2015
|
DOI | 10.1007/s40263-015-0231-5 |
Pubmed ID | |
Authors |
Amy Lanteigne, Yi-han Sheu, Til Stürmer, Virginia Pate, Deb Azrael, Sonja A. Swanson, Matthew Miller |
Abstract |
Antidepressants may increase the risk of fractures by disrupting sensory-motor function, thereby increasing the risk of falls, and by decreasing bone mineral density and consequently increasing the fall- or impact-related risk of fracture. Selective serotonin reuptake inhibitor (SSRI) antidepressants appear to increase fracture risk relative to no treatment, while less is known about the effect of serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants, despite SNRIs being prescribed with increasing frequency. No prior study has directly examined how fracture risk differs among patients initiating SNRIs versus those initiating SSRIs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 20% |
Netherlands | 1 | 20% |
United States | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Scientists | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 15% |
Student > Ph. D. Student | 8 | 15% |
Student > Bachelor | 6 | 11% |
Student > Doctoral Student | 3 | 6% |
Student > Postgraduate | 3 | 6% |
Other | 8 | 15% |
Unknown | 17 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 38% |
Psychology | 5 | 9% |
Nursing and Health Professions | 3 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Economics, Econometrics and Finance | 1 | 2% |
Other | 3 | 6% |
Unknown | 20 | 38% |