| Title |
TREM2 regulates innate immunity in Alzheimer’s disease
|
|---|---|
| Published in |
Journal of Neuroinflammation, April 2018
|
| DOI | 10.1186/s12974-018-1148-y |
| Pubmed ID | |
| Authors |
Jiang-Tao Li, Ying Zhang |
| Abstract |
Recent research has shown that the triggering receptor expressed on myeloid cells 2 (TREM2) in microglia is closely related to the pathogenesis of Alzheimer's disease (AD). The mechanism of this relationship, however, remains unclear. TREM2 is part of the TREM family of receptors, which are expressed primarily in myeloid cells, including monocytes, dendritic cells, and microglia. The TREM family members are cell surface glycoproteins with an immunoglobulin-like extracellular domain, a transmembrane region and a short cytoplasmic tail region. The present article reviews the following: (1) the structure, function, and variant site analysis of the Trem2 gene; (2) the metabolism of TREM2 in peripheral blood and cerebrospinal fluid; and (3) the possible underlying mechanism by which TREM2 regulates innate immunity and participates in AD. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 20% |
| United Kingdom | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 124 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 19% |
| Student > Ph. D. Student | 22 | 18% |
| Student > Bachelor | 15 | 12% |
| Student > Master | 11 | 9% |
| Other | 6 | 5% |
| Other | 11 | 9% |
| Unknown | 35 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 28 | 23% |
| Biochemistry, Genetics and Molecular Biology | 19 | 15% |
| Medicine and Dentistry | 10 | 8% |
| Immunology and Microbiology | 5 | 4% |
| Chemistry | 5 | 4% |
| Other | 15 | 12% |
| Unknown | 42 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2018.
All research outputs
#2,809,521
of 23,043,346 outputs
Outputs from Journal of Neuroinflammation
#443
of 2,659 outputs
Outputs of similar age
#60,179
of 327,682 outputs
Outputs of similar age from Journal of Neuroinflammation
#15
of 83 outputs
Altmetric has tracked 23,043,346 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,659 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,682 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.