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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The structural biology of CRISPR-Cas systems
|
|---|---|
| Published in |
Current Opinion in Structural Biology, February 2015
|
| DOI | 10.1016/j.sbi.2015.02.002 |
| Pubmed ID | |
| Authors |
Fuguo Jiang, Jennifer A Doudna |
| Abstract |
Prokaryotic CRISPR-Cas genomic loci encode RNA-mediated adaptive immune systems that bear some functional similarities with eukaryotic RNA interference. Acquired and heritable immunity against bacteriophage and plasmids begins with integration of ∼30 base pair foreign DNA sequences into the host genome. CRISPR-derived transcripts assemble with CRISPR-associated (Cas) proteins to target complementary nucleic acids for degradation. Here we review recent advances in the structural biology of these targeting complexes, with a focus on structural studies of the multisubunit Type I CRISPR RNA-guided surveillance and the Cas9 DNA endonuclease found in Type II CRISPR-Cas systems. These complexes have distinct structures that are each capable of site-specific double-stranded DNA binding and local helix unwinding. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 33% |
| United Kingdom | 2 | 11% |
| Australia | 1 | 6% |
| Hong Kong | 1 | 6% |
| China | 1 | 6% |
| Unknown | 7 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 61% |
| Scientists | 6 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 761 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | <1% |
| Colombia | 2 | <1% |
| Germany | 2 | <1% |
| Netherlands | 2 | <1% |
| Denmark | 2 | <1% |
| Austria | 1 | <1% |
| Brazil | 1 | <1% |
| India | 1 | <1% |
| Switzerland | 1 | <1% |
| Other | 4 | <1% |
| Unknown | 738 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 145 | 19% |
| Student > Master | 140 | 18% |
| Student > Bachelor | 120 | 16% |
| Researcher | 112 | 15% |
| Student > Doctoral Student | 31 | 4% |
| Other | 84 | 11% |
| Unknown | 129 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 251 | 33% |
| Biochemistry, Genetics and Molecular Biology | 238 | 31% |
| Chemistry | 35 | 5% |
| Immunology and Microbiology | 25 | 3% |
| Medicine and Dentistry | 23 | 3% |
| Other | 50 | 7% |
| Unknown | 139 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2021.
All research outputs
#1,592,313
of 25,371,288 outputs
Outputs from Current Opinion in Structural Biology
#30
of 2,067 outputs
Outputs of similar age
#19,718
of 269,966 outputs
Outputs of similar age from Current Opinion in Structural Biology
#1
of 24 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,067 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,966 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.