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Dosimetry Modeling for Focal Low-Dose-Rate Prostate Brachytherapy

Overview of attention for article published in International Journal of Radiation Oncology, Biology, Physics, April 2015
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Title
Dosimetry Modeling for Focal Low-Dose-Rate Prostate Brachytherapy
Published in
International Journal of Radiation Oncology, Biology, Physics, April 2015
DOI 10.1016/j.ijrobp.2015.02.043
Pubmed ID
Authors

Bashar Al-Qaisieh, Josh Mason, Peter Bownes, Ann Henry, Louise Dickinson, Hashim U. Ahmed, Mark Emberton, Stephen Langley

Abstract

Focal brachytherapy targeted to an individual lesion(s) within the prostate may reduce side effects experienced with whole-gland brachytherapy. The outcomes of a consensus meeting on focal prostate brachytherapy were used to investigate optimal dosimetry of focal low-dose-rate (LDR) prostate brachytherapy targeted using multiparametric magnetic resonance imaging (mp-MRI) and transperineal template prostate mapping (TPM) biopsy, including the effects of random and systematic seed displacements and interseed attenuation (ISA). Nine patients were selected according to clinical characteristics and concordance of TPM and mp-MRI. Retrospectively, 3 treatment plans were analyzed for each case: whole-gland (WG), hemi-gland (hemi), and ultra-focal (UF) plans, with 145-Gy prescription dose and identical dose constraints for each plan. Plan robustness to seed displacement and ISA were assessed using Monte Carlo simulations. WG plans used a mean 28 needles and 81 seeds, hemi plans used 17 needles and 56 seeds, and UF plans used 12 needles and 25 seeds. Mean D90 (minimum dose received by 90% of the target) and V100 (percentage of the target that receives 100% dose) values were 181.3 Gy and 99.8% for the prostate in WG plans, 195.7 Gy and 97.8% for the hemi-prostate in hemi plans, and 218.3 Gy and 99.8% for the focal target in UF plans. Mean urethra D10 was 205.9 Gy, 191.4 Gy, and 92.4 Gy in WG, hemi, and UF plans, respectively. Mean rectum D2 cm(3) was 107.5 Gy, 77.0 Gy, and 42.7 Gy in WG, hemi, and UF plans, respectively. Focal plans were more sensitive to seed displacement errors: random shifts with a standard deviation of 4 mm reduced mean target D90 by 14.0%, 20.5%, and 32.0% for WG, hemi, and UF plans, respectively. ISA has a similar impact on dose-volume histogram parameters for all plan types. Treatment planning for focal LDR brachytherapy is feasible. Dose constraints are easily met with a notable reduction to organs at risk. Treating smaller targets makes seed positioning more critical.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 17%
Other 7 13%
Researcher 7 13%
Student > Ph. D. Student 7 13%
Professor > Associate Professor 5 9%
Other 11 21%
Unknown 7 13%
Readers by discipline Count As %
Medicine and Dentistry 16 30%
Engineering 7 13%
Physics and Astronomy 5 9%
Nursing and Health Professions 3 6%
Computer Science 2 4%
Other 5 9%
Unknown 15 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2015.
All research outputs
#17,313,103
of 25,411,814 outputs
Outputs from International Journal of Radiation Oncology, Biology, Physics
#7,563
of 11,094 outputs
Outputs of similar age
#169,215
of 279,343 outputs
Outputs of similar age from International Journal of Radiation Oncology, Biology, Physics
#115
of 149 outputs
Altmetric has tracked 25,411,814 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,094 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,343 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 149 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.