| Title |
Dedifferentiation, Transdifferentiation, and Proliferation: Mechanisms Underlying Cardiac Muscle Regeneration in Zebrafish
|
|---|---|
| Published in |
Current Pathobiology Reports, January 2015
|
| DOI | 10.1007/s40139-015-0063-5 |
| Pubmed ID | |
| Authors |
Kazu Kikuchi |
| Abstract |
The adult mammalian heart is increasingly recognized as a regenerative organ with a measurable capacity to replenish cardiomyocytes throughout its lifetime, illuminating the possibility of stimulating endogenous regenerative capacity to treat heart diseases. Unlike mammals, certain vertebrates possess robust capacity for regenerating a damaged heart, providing a model to understand how regeneration could be augmented in injured human hearts. Facilitated by its rich history in the study of heart development, the teleost zebrafish Danio rerio has been established as a robust model to investigate the underlying mechanism of cardiac regeneration. This review discusses the current understanding of the endogenous mechanisms behind cardiac regeneration in zebrafish, with a particular focus on cardiomyocyte dedifferentiation, transdifferentiation, and proliferation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | <1% |
| India | 1 | <1% |
| Unknown | 101 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 23% |
| Student > Bachelor | 18 | 17% |
| Student > Master | 16 | 16% |
| Researcher | 14 | 14% |
| Student > Postgraduate | 6 | 6% |
| Other | 11 | 11% |
| Unknown | 14 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 36% |
| Biochemistry, Genetics and Molecular Biology | 26 | 25% |
| Medicine and Dentistry | 12 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Mathematics | 2 | 2% |
| Other | 6 | 6% |
| Unknown | 17 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2015.
All research outputs
#2,717,409
of 26,017,215 outputs
Outputs from Current Pathobiology Reports
#6
of 113 outputs
Outputs of similar age
#37,012
of 367,410 outputs
Outputs of similar age from Current Pathobiology Reports
#1
of 6 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 113 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them