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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Suppression of Inflammatory Immune Responses in Celiac Disease by Experimental Hookworm Infection
|
|---|---|
| Published in |
PLOS ONE, September 2011
|
| DOI | 10.1371/journal.pone.0024092 |
| Pubmed ID | |
| Authors |
Henry J. McSorley, Soraya Gaze, James Daveson, Dianne Jones, Robert P. Anderson, Andrew Clouston, Nathalie E. Ruyssers, Richard Speare, James S. McCarthy, Christian R. Engwerda, John Croese, Alex Loukas |
| Abstract |
We present immunological data from two clinical trials where the effect of experimental human hookworm (Necator americanus) infection on the pathology of celiac disease was evaluated. We found that basal production of Interferon- (IFN-)γ and Interleukin- (IL-)17A from duodenal biopsy culture was suppressed in hookworm-infected participants compared to uninfected controls. Increased levels of CD4+CD25+Foxp3+ cells in the circulation and mucosa are associated with active celiac disease. We show that this accumulation also occurs during a short-term (1 week) oral gluten challenge, and that hookworm infection suppressed the increase of circulating CD4+CD25+Foxp3+ cells during this challenge period. When duodenal biopsies from hookworm-infected participants were restimulated with the immunodominant gliadin peptide QE65, robust production of IL-2, IFN-γ and IL-17A was detected, even prior to gluten challenge while participants were strictly adhering to a gluten-free diet. Intriguingly, IL-5 was produced only after hookworm infection in response to QE65. Thus we hypothesise that hookworm-induced TH2 and IL-10 cross-regulation of the TH1/TH17 inflammatory response may be responsible for the suppression of these responses during experimental hookworm infection. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| United Kingdom | 1 | 20% |
| Canada | 1 | 20% |
| Australia | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 169 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Austria | 1 | <1% |
| Brazil | 1 | <1% |
| Australia | 1 | <1% |
| Canada | 1 | <1% |
| Czechia | 1 | <1% |
| Unknown | 162 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 39 | 23% |
| Researcher | 23 | 14% |
| Student > Ph. D. Student | 21 | 12% |
| Student > Master | 21 | 12% |
| Student > Doctoral Student | 13 | 8% |
| Other | 26 | 15% |
| Unknown | 26 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 50 | 30% |
| Medicine and Dentistry | 33 | 20% |
| Immunology and Microbiology | 22 | 13% |
| Biochemistry, Genetics and Molecular Biology | 12 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Other | 16 | 9% |
| Unknown | 32 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2016.
All research outputs
#1,027,676
of 25,654,806 outputs
Outputs from PLOS ONE
#13,193
of 223,967 outputs
Outputs of similar age
#3,920
of 130,560 outputs
Outputs of similar age from PLOS ONE
#130
of 2,538 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 223,967 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,560 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 2,538 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.