| Title |
A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity
|
|---|---|
| Published in |
Molecular Medicine, February 2015
|
| DOI | 10.2119/molmed.2014.00219 |
| Pubmed ID | |
| Authors |
Christian Hammer, Podchanart Wanitchakool, Lalida Sirianant, Sergi Papiol, Mathieu Monnheimer, Diana Faria, Jiraporn Ousingsawat, Natalie Schramek, Corinna Schmitt, Gabriele Margos, Angelika Michel, Peter Kraiczy, Michael Pawlita, Rainer Schreiber, Thomas F. Schulz, Volker Fingerle, Hayrettin Tumani, Hannelore Ehrenreich, Karl Kunzelmann |
| Abstract |
In a first genome-wide association study (GWAS) approach to anti-Borrelia seropositivity, we identified two significant single nucleotide polymorphisms (SNP) (rs17850869, P=4.17E-09; rs41289586, P=7.18E-08). Both markers, located on chromosomes 16 and 3, respectively, are within or close to genes previously connected to spinocerebellar ataxia. The risk SNP rs41289586 represents a missense variant (R263H) of anoctamin10 (ANO10), a member of a protein family encoding Cl(-) channels and phospholipid scramblases. ANO10 augments volume regulated Cl(-) currents (IHypo) in Xenopus oocytes, HEK293 cells, lymphocytes and macrophages and controls volume regulation by enhancing regulatory volume decrease (RVD). ANO10 supports migration of macrophages, and phagocytosis of spirochetes. The R263H variant is inhibitory on IHypo, RVD and intracellular Ca(2+) signals, which may delay spirochete clearance, thereby sensitizing adaptive immunity. Our data demonstrate for the first time that ANO10 has a central role in innate immune defense against Borrelia infection. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 4% |
| Unknown | 47 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 14% |
| Researcher | 6 | 12% |
| Professor | 5 | 10% |
| Student > Doctoral Student | 4 | 8% |
| Student > Master | 4 | 8% |
| Other | 8 | 16% |
| Unknown | 15 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 8 | 16% |
| Immunology and Microbiology | 5 | 10% |
| Biochemistry, Genetics and Molecular Biology | 4 | 8% |
| Medicine and Dentistry | 3 | 6% |
| Agricultural and Biological Sciences | 3 | 6% |
| Other | 7 | 14% |
| Unknown | 19 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2020.
All research outputs
#6,039,141
of 22,793,427 outputs
Outputs from Molecular Medicine
#296
of 1,136 outputs
Outputs of similar age
#67,551
of 255,222 outputs
Outputs of similar age from Molecular Medicine
#2
of 14 outputs
Altmetric has tracked 22,793,427 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,136 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has gotten more attention than average, scoring higher than 73% of its peers.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.