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Vitamin D and immune function: an overview

Overview of attention for article published in Proceedings of the Nutrition Society, August 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
6 news outlets
blogs
1 blog
twitter
25 X users
facebook
5 Facebook pages
video
1 YouTube creator

Citations

dimensions_citation
311 Dimensions

Readers on

mendeley
429 Mendeley
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Title
Vitamin D and immune function: an overview
Published in
Proceedings of the Nutrition Society, August 2011
DOI 10.1017/s0029665111001650
Pubmed ID
Authors

Martin Hewison

Abstract

Immunomodulatory actions of vitamin D have been recognised for over a quarter of a century, but it is only in the last few years that the significance of this to normal human physiology has become apparent. Two key factors have underpinned this revised perspective. Firstly, there are increasing data linking vitamin insufficiency with prevalent immune disorders. Improved awareness of low circulating levels of precursor 25-hydroxyvitamin D in populations across the globe has prompted epidemiological investigations of health problems associated with vitamin D insufficiency. Prominent among these are autoimmune diseases such as multiple sclerosis, type 1 diabetes and Crohn's disease, but more recent studies indicate that infections such as tuberculosis may also be linked to low 25-hydroxyvitamin D levels. The second factor expanding the link between vitamin D and the immune system is our improved knowledge of the mechanisms that facilitate this association. It is now clear that cells from the immune system contain all the machinery needed to convert 25-hydroxyvitamin D to active 1,25-dihydroxyvitamin D, and for subsequent responses to 1,25-dihydroxyvitamin D. Mechanisms such as this are important for promoting antimicrobial responses to pathogens in macrophages, and for regulating the maturation of antigen-presenting dendritic cells. The latter may be a key pathway by which vitamin D controls T-lymphocyte (T-cell) function. However, T-cells also exhibit direct responses to 1,25-dihydroxyvitamin D, notably the development of suppressor regulatory T-cells. Collectively these observations suggest that vitamin D is a key factor linking innate and adaptive immunity, and both of these functions may be compromised under conditions of vitamin D insufficiency.

X Demographics

X Demographics

The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 429 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 2 <1%
United Kingdom 2 <1%
United States 2 <1%
Brazil 1 <1%
Portugal 1 <1%
Japan 1 <1%
Australia 1 <1%
Unknown 419 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 55 13%
Student > Master 55 13%
Student > Bachelor 50 12%
Student > Ph. D. Student 36 8%
Student > Postgraduate 33 8%
Other 87 20%
Unknown 113 26%
Readers by discipline Count As %
Medicine and Dentistry 123 29%
Agricultural and Biological Sciences 49 11%
Biochemistry, Genetics and Molecular Biology 30 7%
Nursing and Health Professions 27 6%
Immunology and Microbiology 14 3%
Other 49 11%
Unknown 137 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 75. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2023.
All research outputs
#571,568
of 25,371,288 outputs
Outputs from Proceedings of the Nutrition Society
#70
of 1,703 outputs
Outputs of similar age
#2,105
of 133,392 outputs
Outputs of similar age from Proceedings of the Nutrition Society
#1
of 17 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,703 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 133,392 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.