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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women
|
|---|---|
| Published in |
Experimental Gerontology, February 2015
|
| DOI | 10.1016/j.exger.2015.02.015 |
| Pubmed ID | |
| Authors |
Melissa M. Markofski, Jared M. Dickinson, Micah J. Drummond, Christopher S. Fry, Satoshi Fujita, David M. Gundermann, Erin L. Glynn, Kristofer Jennings, Douglas Paddon-Jones, Paul T. Reidy, Melinda Sheffield-Moore, Kyle L. Timmerman, Blake B. Rasmussen, Elena Volpi |
| Abstract |
The rate of muscle loss with aging is higher in men than women. However, women have smaller muscles throughout the adult life. Protein content is a major determinant of skeletal muscle size. This study was designed to determine if age and sex differentially impact basal muscle protein synthesis and mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling. We performed a secondary data analysis on a cohort of 215 healthy, non-obese (BMI<30kg·m(-2)) young (18-40y; 74 men, 52 women) and older (60-87y; 57 men, 32 women) adults. The database contained information on physical characteristics, basal muscle protein fractional synthetic rate (FSR; n=215; stable isotope methodology) and mTORC1 signaling (n=125, Western blotting). FSR and mTORC1 signaling were measured at rest and after an overnight fast. mTORC1 and S6K1 phosphorylation were higher (p<0.05) in older subjects with no sex differences. However, there were no age or sex differences or interaction for muscle FSR (p>0.05). Body mass index, fat free mass, or body fat was not a significant covariate and did not influence the results. We conclude that age and sex do not influence basal muscle protein synthesis. However, basal mTORC1 hyperphosphorylation in the elderly may contribute to insulin resistance and the age-related anabolic resistance of skeletal muscle protein metabolism to nutrition and exercise. |
X Demographics
The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 10 | 29% |
| United States | 5 | 15% |
| Canada | 2 | 6% |
| France | 2 | 6% |
| Finland | 1 | 3% |
| India | 1 | 3% |
| Norway | 1 | 3% |
| Costa Rica | 1 | 3% |
| Germany | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 7 | 21% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 41% |
| Scientists | 12 | 35% |
| Practitioners (doctors, other healthcare professionals) | 7 | 21% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 204 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Poland | 1 | <1% |
| Unknown | 201 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 37 | 18% |
| Student > Ph. D. Student | 33 | 16% |
| Researcher | 29 | 14% |
| Student > Bachelor | 19 | 9% |
| Professor | 10 | 5% |
| Other | 29 | 14% |
| Unknown | 47 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 33 | 16% |
| Medicine and Dentistry | 28 | 14% |
| Agricultural and Biological Sciences | 26 | 13% |
| Sports and Recreations | 26 | 13% |
| Nursing and Health Professions | 11 | 5% |
| Other | 19 | 9% |
| Unknown | 61 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2024.
All research outputs
#1,149,427
of 25,374,917 outputs
Outputs from Experimental Gerontology
#133
of 2,798 outputs
Outputs of similar age
#14,226
of 270,421 outputs
Outputs of similar age from Experimental Gerontology
#1
of 34 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,798 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,421 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.