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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome-wide association study identifies five new schizophrenia loci
|
|---|---|
| Published in |
Nature Genetics, September 2011
|
| DOI | 10.1038/ng.940 |
| Pubmed ID | |
| Abstract |
We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 × 10(-11)) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10(-9)), ANK3 (rs10994359, P = 2.5 × 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10(-9)). |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 22% |
| United Kingdom | 2 | 9% |
| France | 1 | 4% |
| Brazil | 1 | 4% |
| Singapore | 1 | 4% |
| Peru | 1 | 4% |
| Unknown | 12 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 78% |
| Scientists | 4 | 17% |
| Unknown | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,360 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 20 | 1% |
| United Kingdom | 19 | 1% |
| Germany | 9 | <1% |
| Australia | 4 | <1% |
| Japan | 4 | <1% |
| Netherlands | 3 | <1% |
| Ireland | 3 | <1% |
| Mexico | 3 | <1% |
| Switzerland | 2 | <1% |
| Other | 16 | 1% |
| Unknown | 1277 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 290 | 21% |
| Researcher | 252 | 19% |
| Student > Bachelor | 162 | 12% |
| Student > Master | 148 | 11% |
| Professor | 71 | 5% |
| Other | 266 | 20% |
| Unknown | 171 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 366 | 27% |
| Medicine and Dentistry | 200 | 15% |
| Biochemistry, Genetics and Molecular Biology | 166 | 12% |
| Neuroscience | 157 | 12% |
| Psychology | 105 | 8% |
| Other | 125 | 9% |
| Unknown | 241 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 88. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2023.
All research outputs
#494,615
of 26,017,215 outputs
Outputs from Nature Genetics
#994
of 7,655 outputs
Outputs of similar age
#1,823
of 145,367 outputs
Outputs of similar age from Nature Genetics
#2
of 85 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,655 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.8. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 145,367 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.