Title |
Protective Effects of Isoliquiritigenin on LPS-Induced Acute Lung Injury by Activating PPAR-γ
|
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Published in |
Inflammation, April 2018
|
DOI | 10.1007/s10753-018-0777-8 |
Pubmed ID | |
Authors |
Wenbin Zhang, Gui Wang, Shujun Zhou |
Abstract |
Isoliquiritigenin (ILG), a major ingredient of licorice, has been reported to have anti-oxidative and anti-inflammatory effects. The aim of this study was to investigate the protective effects of ILG on lung injury using an animal model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Male BALB/c mice were conditioned with ILG 1 h before intranasal instillation of LPS. The effects of ILG on lung injury were assessed by measuring lung histopathological examination, MPO assay, wet/dry (W/D) ratio, and inflammatory cytokine production. The results showed that ILG significantly inhibited LPS-induced lung histopathological changes and the MPO activity. Meanwhile, it attenuated the wet/dry (W/D) ratio in the lung tissues. The results also indicated that ILG inhibited LPS-induced ALI in the expression of inflammatory cytokines in the BALF. Furthermore, ILG can decrease the activity of NF-κB and can increase the expression of PPAR-γ. These findings suggested that ILG inhibited the inflammatory of LPS-induced lung injury by activating PPAR-γ and inhibiting NF-κB activation. |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 2 | 13% |
Researcher | 2 | 13% |
Student > Bachelor | 1 | 7% |
Lecturer | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Other | 1 | 7% |
Unknown | 7 | 47% |
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Medicine and Dentistry | 1 | 7% |
Unknown | 8 | 53% |