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Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

Overview of attention for article published in Nature Communications, March 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

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Title
Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
Published in
Nature Communications, March 2015
DOI 10.1038/ncomms7422
Pubmed ID
Authors

Mohammed Eslam, Ahmed M. Hashem, Reynold Leung, Manuel Romero-Gomez, Thomas Berg, Gregory J. Dore, Henry L.K. Chan, William L. Irving, David Sheridan, Maria L. Abate, Leon A. Adams, Alessandra Mangia, Martin Weltman, Elisabetta Bugianesi, Ulrich Spengler, Olfat Shaker, Janett Fischer, Lindsay Mollison, Wendy Cheng, Elizabeth Powell, Jacob Nattermann, Stephen Riordan, Duncan McLeod, Nicola J. Armstrong, Mark W. Douglas, Christopher Liddle, David R. Booth, Jacob George, Golo Ahlenstiel

Abstract

Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P<0.0001 for all). The impact of rs12979860 genotypes on fibrosis is maximal in young females, especially those with HCV genotype 3. These findings establish rs12979860 genotype as a strong aetiology-independent predictor of tissue inflammation and fibrosis.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 2 2%
Spain 2 2%
Canada 1 <1%
Unknown 113 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 17%
Student > Ph. D. Student 17 14%
Student > Master 11 9%
Student > Doctoral Student 9 8%
Professor > Associate Professor 8 7%
Other 33 28%
Unknown 20 17%
Readers by discipline Count As %
Medicine and Dentistry 39 33%
Biochemistry, Genetics and Molecular Biology 17 14%
Agricultural and Biological Sciences 15 13%
Immunology and Microbiology 7 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 9 8%
Unknown 28 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2019.
All research outputs
#1,251,749
of 22,793,427 outputs
Outputs from Nature Communications
#18,250
of 46,925 outputs
Outputs of similar age
#17,189
of 257,881 outputs
Outputs of similar age from Nature Communications
#235
of 767 outputs
Altmetric has tracked 22,793,427 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,925 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,881 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 767 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.