Title |
Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
|
---|---|
Published in |
Nature Communications, March 2015
|
DOI | 10.1038/ncomms7422 |
Pubmed ID | |
Authors |
Mohammed Eslam, Ahmed M. Hashem, Reynold Leung, Manuel Romero-Gomez, Thomas Berg, Gregory J. Dore, Henry L.K. Chan, William L. Irving, David Sheridan, Maria L. Abate, Leon A. Adams, Alessandra Mangia, Martin Weltman, Elisabetta Bugianesi, Ulrich Spengler, Olfat Shaker, Janett Fischer, Lindsay Mollison, Wendy Cheng, Elizabeth Powell, Jacob Nattermann, Stephen Riordan, Duncan McLeod, Nicola J. Armstrong, Mark W. Douglas, Christopher Liddle, David R. Booth, Jacob George, Golo Ahlenstiel |
Abstract |
Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P<0.0001 for all). The impact of rs12979860 genotypes on fibrosis is maximal in young females, especially those with HCV genotype 3. These findings establish rs12979860 genotype as a strong aetiology-independent predictor of tissue inflammation and fibrosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 14% |
Saudi Arabia | 1 | 14% |
United Kingdom | 1 | 14% |
Belgium | 1 | 14% |
Egypt | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Scientists | 2 | 29% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | 2% |
Spain | 2 | 2% |
Canada | 1 | <1% |
Unknown | 113 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 17% |
Student > Ph. D. Student | 17 | 14% |
Student > Master | 11 | 9% |
Student > Doctoral Student | 9 | 8% |
Professor > Associate Professor | 8 | 7% |
Other | 33 | 28% |
Unknown | 20 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 39 | 33% |
Biochemistry, Genetics and Molecular Biology | 17 | 14% |
Agricultural and Biological Sciences | 15 | 13% |
Immunology and Microbiology | 7 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 9 | 8% |
Unknown | 28 | 24% |