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A Phase 1 Trial of MSP2-C1, a Blood-Stage Malaria Vaccine Containing 2 Isoforms of MSP2 Formulated with Montanide® ISA 720

Overview of attention for article published in PLOS ONE, September 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

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2 X users
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1 patent

Citations

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Title
A Phase 1 Trial of MSP2-C1, a Blood-Stage Malaria Vaccine Containing 2 Isoforms of MSP2 Formulated with Montanide® ISA 720
Published in
PLOS ONE, September 2011
DOI 10.1371/journal.pone.0024413
Pubmed ID
Authors

James S. McCarthy, Joanne Marjason, Suzanne Elliott, Paul Fahey, Gilles Bang, Elissa Malkin, Eveline Tierney, Hayley Aked-Hurditch, Christopher Adda, Nadia Cross, Jack S. Richards, Freya J. I. Fowkes, Michelle J. Boyle, Carole Long, Pierre Druilhe, James G. Beeson, Robin F. Anders

Abstract

In a previous Phase 1/2b malaria vaccine trial testing the 3D7 isoform of the malaria vaccine candidate Merozoite surface protein 2 (MSP2), parasite densities in children were reduced by 62%. However, breakthrough parasitemias were disproportionately of the alternate dimorphic form of MSP2, the FC27 genotype. We therefore undertook a dose-escalating, double-blinded, placebo-controlled Phase 1 trial in healthy, malaria-naïve adults of MSP2-C1, a vaccine containing recombinant forms of the two families of msp2 alleles, 3D7 and FC27 (EcMSP2-3D7 and EcMSP2-FC27), formulated in equal amounts with Montanide® ISA 720 as a water-in-oil emulsion.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Sweden 1 1%
Kenya 1 1%
Pakistan 1 1%
Unknown 79 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 18%
Student > Master 14 17%
Student > Bachelor 9 11%
Researcher 9 11%
Other 5 6%
Other 17 20%
Unknown 14 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 27%
Medicine and Dentistry 14 17%
Biochemistry, Genetics and Molecular Biology 13 16%
Immunology and Microbiology 7 8%
Chemistry 3 4%
Other 9 11%
Unknown 15 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2018.
All research outputs
#6,374,317
of 22,651,245 outputs
Outputs from PLOS ONE
#76,232
of 193,366 outputs
Outputs of similar age
#37,120
of 130,474 outputs
Outputs of similar age from PLOS ONE
#821
of 2,539 outputs
Altmetric has tracked 22,651,245 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 193,366 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,474 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 2,539 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.