Title |
A Phase 1 Trial of MSP2-C1, a Blood-Stage Malaria Vaccine Containing 2 Isoforms of MSP2 Formulated with Montanide® ISA 720
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Published in |
PLOS ONE, September 2011
|
DOI | 10.1371/journal.pone.0024413 |
Pubmed ID | |
Authors |
James S. McCarthy, Joanne Marjason, Suzanne Elliott, Paul Fahey, Gilles Bang, Elissa Malkin, Eveline Tierney, Hayley Aked-Hurditch, Christopher Adda, Nadia Cross, Jack S. Richards, Freya J. I. Fowkes, Michelle J. Boyle, Carole Long, Pierre Druilhe, James G. Beeson, Robin F. Anders |
Abstract |
In a previous Phase 1/2b malaria vaccine trial testing the 3D7 isoform of the malaria vaccine candidate Merozoite surface protein 2 (MSP2), parasite densities in children were reduced by 62%. However, breakthrough parasitemias were disproportionately of the alternate dimorphic form of MSP2, the FC27 genotype. We therefore undertook a dose-escalating, double-blinded, placebo-controlled Phase 1 trial in healthy, malaria-naïve adults of MSP2-C1, a vaccine containing recombinant forms of the two families of msp2 alleles, 3D7 and FC27 (EcMSP2-3D7 and EcMSP2-FC27), formulated in equal amounts with Montanide® ISA 720 as a water-in-oil emulsion. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Sweden | 1 | 1% |
Kenya | 1 | 1% |
Pakistan | 1 | 1% |
Unknown | 79 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 15 | 18% |
Student > Master | 14 | 17% |
Student > Bachelor | 9 | 11% |
Researcher | 9 | 11% |
Other | 5 | 6% |
Other | 17 | 20% |
Unknown | 14 | 17% |
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Medicine and Dentistry | 14 | 17% |
Biochemistry, Genetics and Molecular Biology | 13 | 16% |
Immunology and Microbiology | 7 | 8% |
Chemistry | 3 | 4% |
Other | 9 | 11% |
Unknown | 15 | 18% |